{"id":"W2134454299","doi":"10.3390/biom2020269","title":"DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals","year":2012,"lang":"en","type":"article","venue":"Biomolecules","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Technische Universität Dresden","keywords":"Exocytosis; Insulin; Cell biology; Secretion; Glucose homeostasis; Biology; SUMO protein; Beta cell; Internal medicine; Endocrinology; Islet; Biochemistry; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946561,0.0001974253,0.0003120021,0.000116526,0.000167106,0.0005373939,0.0002199628,0.0001985136,0.0007695983],"category_scores_gemma":[0.0001844758,0.0001493679,0.0002162882,0.0001188131,0.0002812441,0.0005180468,0.0003341352,0.0003565013,0.0002269979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002779136,"about_ca_system_score_gemma":0.00009423733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001233675,"about_ca_topic_score_gemma":0.0001590441,"domain_scores_codex":[0.999885,0.00002187846,0.00001159775,0.00003432862,0.00001846374,0.00002878613],"domain_scores_gemma":[0.999896,0.00002480691,0.00002916547,0.00001624266,0.000009558654,0.00002417658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002160197,0.000006648726,0.0002400717,0.00001587397,0.000002632549,0.00003723976,0.00001681873,0.00005392069,0.9983992,0.0001442433,0.000009529493,0.0008579043],"study_design_scores_gemma":[0.0000113605,0.0000652821,0.005248406,0.000002052973,0.000006387633,0.00009740733,0.00003977946,0.0008842259,0.9923888,0.0001212594,0.001130221,0.000004881937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953824,0.001185488,0.002445217,0.0001050355,0.00001756823,0.000008484527,0.00006630434,0.00004609178,0.0007433578],"genre_scores_gemma":[0.9978766,0.0006145877,0.0008186465,0.00002346189,0.000007464927,0.000007200013,0.00006472087,0.00001076364,0.0005765066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007695983,"threshold_uncertainty_score":0.002574503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556620244867531,"score_gpt":0.2939019775053572,"score_spread":0.2683357750566819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}