{"id":"W2134471459","doi":"10.1371/journal.pgen.1002805","title":"A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation","year":2012,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; National Center for Advancing Translational Sciences; Medical Research Council; U.S. Public Health Service; Directorate for Biological Sciences; National Institutes of Health; National Cancer Institute; Ministry of Cultural Affairs; Universität Greifswald; Turun Yliopistollinen Keskussairaala; Siemens; Broad Institute; Juho Vainion Säätiö; ZonMw; Suomen Kulttuurirahasto; Novo Nordisk; Paavo Nurmen Säätiö; Erasmus Medisch Centrum; National Institute on Minority Health and Health Disparities; Tampereen Tuberkuloosisäätiö; Kela; National Eye Institute; Academy of Finland; King's College London; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Oulun Yliopisto; Helsingin Yliopisto; European Commission; Emil Aaltosen Säätiö; Pfizer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biotechnology and Biological Sciences Research Council; Wellcome Trust; National Science Foundation","keywords":"Biology; Sex hormone-binding globulin; Genome-wide association study; Sex steroid; Hormone; Genetics; Steroid hormone; Meta-analysis; Genetic association; Internal medicine; Endocrinology; Gene; Steroid; Single-nucleotide polymorphism; Genotype; Androgen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001429738,0.0006299253,0.006137601,0.0008639538,0.0001089761,0.00002155993,0.0001986879,0.0005285414,0.00003220661],"category_scores_gemma":[0.000802139,0.0004893381,0.001887591,0.002151171,0.00006103908,0.00005862364,0.0002025168,0.0005013297,0.00002687673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008408868,"about_ca_system_score_gemma":0.0001014163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002097907,"about_ca_topic_score_gemma":0.0000165768,"domain_scores_codex":[0.99518,0.0004782012,0.002006027,0.0008489453,0.0008954554,0.0005914008],"domain_scores_gemma":[0.9959001,0.0006916814,0.002000292,0.0008061852,0.0004498127,0.0001519632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00007864616,0.001564255,0.09481025,0.01402311,0.7833292,0.00002827432,0.003796616,0.0006157488,0.03121665,0.000004326816,0.000155809,0.07037705],"study_design_scores_gemma":[0.0007452254,0.0002098279,0.1124819,0.0003137743,0.8581998,0.000008750363,0.0002346662,0.0005857812,0.0003295184,0.0000311476,0.02593477,0.000924751],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04436924,0.9531978,0.00005197103,0.00007788485,0.00002320363,0.001819633,0.0002279429,0.00004300143,0.0001893665],"genre_scores_gemma":[0.1666131,0.8301212,0.0006217135,0.00002099627,0.0002688351,0.0001984525,0.001260539,0.00009346291,0.0008016683],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1230765,"threshold_uncertainty_score":0.9997558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1565901826361227,"score_gpt":0.3367596594516288,"score_spread":0.1801694768155061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}