{"id":"W2134471459","doi":"10.1371/journal.pgen.1002805","title":"A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation","year":2012,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; National Center for Advancing Translational Sciences; Medical Research Council; U.S. Public Health Service; Directorate for Biological Sciences; National Institutes of Health; National Cancer Institute; Ministry of Cultural Affairs; Universität Greifswald; Turun Yliopistollinen Keskussairaala; Siemens; Broad Institute; Juho Vainion Säätiö; ZonMw; Suomen Kulttuurirahasto; Novo Nordisk; Paavo Nurmen Säätiö; Erasmus Medisch Centrum; National Institute on Minority Health and Health Disparities; Tampereen Tuberkuloosisäätiö; Kela; National Eye Institute; Academy of Finland; King's College London; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Oulun Yliopisto; Helsingin Yliopisto; European Commission; Emil Aaltosen Säätiö; Pfizer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biotechnology and Biological Sciences Research Council; Wellcome Trust; National Science Foundation","keywords":"Biology; Sex hormone-binding globulin; Genome-wide association study; Sex steroid; Hormone; Genetics; Steroid hormone; Meta-analysis; Genetic association; Internal medicine; Endocrinology; Gene; Steroid; Single-nucleotide polymorphism; Genotype; Androgen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00563371,0.001956522,0.004057308,0.002692021,0.001070739,0.002570681,0.001273228,0.001419981,0.002658098],"category_scores_gemma":[0.007967156,0.0008290617,0.01443795,0.004970882,0.0005909754,0.0006506249,0.001360088,0.00189063,0.0002926898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007313967,"about_ca_system_score_gemma":0.001000194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01440758,"about_ca_topic_score_gemma":0.01682279,"domain_scores_codex":[0.9954997,0.001716612,0.0004189796,0.001505665,0.0004899048,0.0003690762],"domain_scores_gemma":[0.9950756,0.002860119,0.0005962543,0.000747859,0.0004317753,0.0002883603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006601635,0.00006486438,0.5241029,0.003129889,0.4387269,0.001005506,0.0001795307,0.001931915,0.005279382,0.0004057163,0.002517521,0.01605416],"study_design_scores_gemma":[0.0008583149,0.0005409627,0.4659201,0.0005162347,0.5220436,0.0008825286,0.0001640564,0.003666258,0.0011218,0.001020213,0.003208899,0.00005702177],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7231359,0.2559968,0.009004121,0.00235612,0.0007248658,0.00008922419,0.00596955,0.0004941383,0.002229159],"genre_scores_gemma":[0.9826967,0.01243936,0.002047636,0.0004325469,0.00016867,0.00005463951,0.001603621,0.00007888969,0.000478068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01440758,"threshold_uncertainty_score":0.02979428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1565901826361227,"score_gpt":0.3367596594516288,"score_spread":0.1801694768155061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}