{"id":"W2134503542","doi":"10.1039/c1an15352h","title":"A single DNA aptamer functions as a biosensor for ricin","year":2011,"lang":"en","type":"article","venue":"The Analyst","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Centers for Disease Control and Prevention; U.S. Department of Homeland Security","keywords":"Ricin; Aptamer; Chemistry; DNA; Biochemistry; Biosensor; Toxin; Detection limit; Computational biology; Molecular biology; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001915047,0.000124229,0.0001811325,0.00007996601,0.00034475,0.00001132969,0.0002236384,0.000111957,0.00162417],"category_scores_gemma":[0.00004306552,0.00007907705,0.0001806534,0.0001635419,0.0001266583,0.00004625233,0.00004476093,0.000123312,0.002383158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001705774,"about_ca_system_score_gemma":0.00002114673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003495104,"about_ca_topic_score_gemma":0.00008181528,"domain_scores_codex":[0.999258,0.0000792551,0.0001838902,0.0001860013,0.00001936646,0.0002734586],"domain_scores_gemma":[0.9993795,0.00007110435,0.00008253417,0.000398566,0.00005476656,0.00001356086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141769,0.0001690522,0.00002441464,0.000002754211,0.0003418295,0.000001302834,0.0007395786,3.06028e-7,0.9839804,0.006737382,0.004955496,0.0029057],"study_design_scores_gemma":[0.0009649693,0.0007529981,0.001090643,0.00001207534,0.0004044849,0.00005047715,0.002161287,0.000006627622,0.6341976,0.002084046,0.3580511,0.0002237412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567317,0.001960342,0.008097187,0.0007799205,0.001456492,0.0007616018,0.0001097827,0.0001943516,0.02990861],"genre_scores_gemma":[0.9630029,0.00001337302,0.0002510626,0.0004687123,0.00004000257,0.000051159,0.00003650154,0.00001691872,0.03611939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3530956,"threshold_uncertainty_score":0.9992885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03852270690736854,"score_gpt":0.2339423183701971,"score_spread":0.1954196114628286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}