{"id":"W2134504418","doi":"10.1002/chin.201001152","title":"ChemInform Abstract: An Improved Synthesis of Pyridine—Thiazole Cores of Thiopeptide Antibiotics.","year":2009,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Thiazole; Pyridine; Combinatorial chemistry; Antibiotics; Service (business); Stereochemistry; Organic chemistry; Biochemistry; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002444978,0.0002788333,0.0005809047,0.00003471483,0.00004790384,0.00002035758,0.0004932949,0.0003412881,0.002059354],"category_scores_gemma":[0.0005325912,0.0002093552,0.0002349368,0.0001201565,0.000188267,0.0002816072,0.00007035257,0.0002008346,0.000009562001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004759727,"about_ca_system_score_gemma":0.00005678747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005566763,"about_ca_topic_score_gemma":0.000004186503,"domain_scores_codex":[0.998467,9.623938e-8,0.0006681266,0.0002562779,0.0002524119,0.0003560784],"domain_scores_gemma":[0.9983611,0.0002465479,0.0005454518,0.0005577494,0.0001399853,0.0001492205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008664207,0.0002473922,0.0002518073,0.0001645918,0.00002469765,9.339924e-7,0.00006515684,1.257918e-7,0.5890501,0.00005171049,0.0003611055,0.4096958],"study_design_scores_gemma":[0.0002201763,0.0000783664,0.008151254,0.0001256074,0.00003787691,0.000005418603,0.0002848338,0.00004680528,0.9894717,0.0001041203,0.001206747,0.0002671359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5042126,0.00003050013,5.169282e-8,0.00003574956,0.00001630081,0.00004639003,0.00005530007,0.00004926333,0.4955539],"genre_scores_gemma":[0.9982149,0.00007539819,0.00009567435,0.00005270008,0.0001034796,0.000001707826,0.00003537273,0.0000125422,0.001408243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4941456,"threshold_uncertainty_score":0.9988529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737928541734509,"score_gpt":0.2412459017626237,"score_spread":0.2238666163452786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}