{"id":"W2134581713","doi":"10.1073/pnas.2628027100","title":"Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"AMPA receptor; Hippocampal formation; Neuroprotection; Ischemia; Hypothermia; Hippocampus; Dentate gyrus; Glutamate receptor; In situ hybridization; Brain ischemia; Forebrain; Endocrinology; Neuroscience; Internal medicine; Biology; Receptor; Anesthesia; Cell biology; Medicine; Messenger RNA; Central nervous system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170879,0.0005227288,0.0005638247,0.0001752996,0.0001079047,0.0002117161,0.0002347812,0.0001955382,0.0006442285],"category_scores_gemma":[0.0001168976,0.0002020471,0.000305797,0.00008579276,0.0002071429,0.0001548097,0.0001740434,0.0005353706,0.0001988581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601783,"about_ca_system_score_gemma":0.0002454495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009807055,"about_ca_topic_score_gemma":0.001829734,"domain_scores_codex":[0.999928,0.000007203889,0.000009471004,0.00001599212,0.00001292242,0.00002656353],"domain_scores_gemma":[0.9999239,0.000005326306,0.00003470929,0.00001219264,0.000007016122,0.00001680123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002572277,0.00003848033,0.0001962217,0.00006212599,0.00001508807,0.00004125735,0.00002026796,0.00007656421,0.9975902,0.00003936031,0.00004772978,0.001615478],"study_design_scores_gemma":[0.0001200203,0.002517543,0.02956254,0.00003139094,0.00009570532,0.0003646398,0.00004538484,0.0008583483,0.9646572,0.0001023884,0.001631052,0.00001372851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969462,0.00144021,0.0007701947,0.00004904349,0.00002022988,0.00003027614,0.0002369923,0.0001178724,0.0003890399],"genre_scores_gemma":[0.9955233,0.001499109,0.0007721196,0.00004613816,0.00001944861,0.00006029867,0.000571174,0.00002594799,0.001482334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009807055,"threshold_uncertainty_score":0.002155185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04098218046483035,"score_gpt":0.2681613723808588,"score_spread":0.2271791919160285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}