{"id":"W2134624875","doi":"10.1128/aac.01400-06","title":"Role of Homoserine Transacetylase as a New Target for Antifungal Agents","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"McMaster University; University of Guelph","keywords":"Homoserine; Cryptococcus neoformans; Complementation; Mutant; Auxotrophy; Biology; Microbiology; Biochemistry; Quorum sensing; Biosynthesis; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175947,0.0001570267,0.0003229502,0.00007252291,0.0001036085,0.00001212622,0.00004287313,0.00007758784,0.0002996692],"category_scores_gemma":[0.00001298155,0.0001322246,0.0001473462,0.0001204306,0.00006571139,0.00004516349,0.00001048483,0.00007042647,0.000004842255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001306614,"about_ca_system_score_gemma":0.00004660097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001795216,"about_ca_topic_score_gemma":0.00001711938,"domain_scores_codex":[0.9992053,0.000005004311,0.0002507681,0.0002062137,0.00008543918,0.000247292],"domain_scores_gemma":[0.999577,0.00002125795,0.00006397497,0.0001216163,0.00006890466,0.000147261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002928767,0.001428608,0.06275462,0.0003737794,0.0008554006,0.00002124284,0.002229366,0.000003878618,0.7039022,0.000338657,0.1543259,0.07083748],"study_design_scores_gemma":[0.008217081,0.001369871,0.09043794,0.0001341784,0.0001278994,0.00008745928,0.0002219452,0.00009819548,0.4633655,0.0002525684,0.4354033,0.0002840779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947584,0.0001438182,0.001355331,0.001481978,0.0001140369,0.0004399171,0.00003223904,0.00002944472,0.001644884],"genre_scores_gemma":[0.9889464,0.001076437,0.003026804,0.003961227,0.0001975395,0.00000333577,0.00002424251,0.00003043967,0.002733557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2810774,"threshold_uncertainty_score":0.5391964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297245101819484,"score_gpt":0.285010807914649,"score_spread":0.2720383568964542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}