{"id":"W2134659798","doi":"10.1038/89631","title":"Interhelical hydrogen bonds in the CFTR membrane domain.","year":2001,"lang":"en","type":"article","venue":"Nature Structural Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institute for Health and Care Research; Cystic Fibrosis Canada; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Hydrogen bond; Cystic fibrosis transmembrane conductance regulator; Chemistry; Transmembrane domain; Biophysics; Helix (gastropod); Protein structure; Membrane protein; Crystallography; Circular dichroism; Transmembrane protein; Static electricity; Alpha helix; Membrane; Biochemistry; Biology; Receptor; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320603,0.0001671403,0.0003040955,0.0001316884,0.00005905998,0.00001249805,0.0003270324,0.0003881199,0.0003868695],"category_scores_gemma":[0.0004951876,0.00008680758,0.00007788416,0.0004058342,0.0002992984,0.00005025475,0.00008120897,0.001326875,0.00002986114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006922898,"about_ca_system_score_gemma":0.00004408406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003527456,"about_ca_topic_score_gemma":0.0001154009,"domain_scores_codex":[0.9985957,0.0001598844,0.0002318846,0.0003231679,0.0002230211,0.0004663071],"domain_scores_gemma":[0.9992076,0.0002650387,0.00004087791,0.0003360535,0.00005615047,0.00009430026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003109965,0.00006595837,0.0693638,0.00009128133,0.0001342309,0.0008292766,0.0007864033,0.000007929112,0.856941,0.02239733,0.003101283,0.04317147],"study_design_scores_gemma":[0.007404788,0.002959862,0.3312127,0.000144686,0.00006710566,0.009896519,0.000942199,0.0005879846,0.02402134,0.05983812,0.5622263,0.0006983988],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825569,0.002635766,0.000008004723,0.00998612,0.0001358532,0.0003464438,0.00001644705,0.00003549488,0.004278991],"genre_scores_gemma":[0.9960734,0.00007529862,0.001102402,0.0021058,0.0003644519,0.0000174941,0.0001112675,0.00001051883,0.0001393268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8329197,"threshold_uncertainty_score":0.5764685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009292929571725327,"score_gpt":0.3421910390990445,"score_spread":0.3328981095273191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}