{"id":"W2134798246","doi":"10.1186/1753-6561-8-s1-s101","title":"Pathway-based analysis of rare and common variants to test for association with blood pressure","year":2014,"lang":"en","type":"article","venue":"BMC Proceedings","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; McMaster University","keywords":"Blood pressure; Medicine; Diastole; Phenotype; Gene; Internal medicine; Cardiology; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00709708,0.0007767125,0.001072074,0.00369521,0.0008101912,0.001199796,0.001073846,0.0007084599,0.005526119],"category_scores_gemma":[0.01956986,0.0002748689,0.002506902,0.003261777,0.000656922,0.0007466812,0.001771768,0.001206815,0.0003924436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004137649,"about_ca_system_score_gemma":0.001564825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002372798,"about_ca_topic_score_gemma":0.002381128,"domain_scores_codex":[0.9937968,0.003681947,0.0004723053,0.0008975888,0.0007129108,0.0004383879],"domain_scores_gemma":[0.9834802,0.01279809,0.001383614,0.001027083,0.0006170485,0.0006938982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003731871,0.0004320363,0.8624154,0.0005988145,0.008128101,0.001484378,0.0003283992,0.01057688,0.04034302,0.004900729,0.001163158,0.06589717],"study_design_scores_gemma":[0.0007681146,0.002953487,0.7857435,0.00009752619,0.004347808,0.005278538,0.0007871305,0.1504584,0.01664434,0.02729772,0.005476396,0.0001470574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8597708,0.0009573846,0.1322538,0.0006489091,0.00008651416,0.0002624275,0.00347238,0.0008694819,0.001678389],"genre_scores_gemma":[0.9546981,0.0001432408,0.04300615,0.0001169631,0.00002280123,0.0002137304,0.001266693,0.00008107007,0.0004512782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00709708,"threshold_uncertainty_score":0.0375334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008784523358285619,"score_gpt":0.2341814608069609,"score_spread":0.2253969374486753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}