{"id":"W2134801815","doi":"10.1021/cb900190u","title":"Synergistic Interplay between Promoter Recognition and CBP/p300 Coactivator Recruitment by FOXO3a","year":2009,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Coactivator; Transactivation; Transcription factor; Histone acetyltransferase; Biology; P300-CBP Transcription Factors; CREB-binding protein; DNA-binding protein; Cell biology; Transcription (linguistics); DNA-binding domain; Plasma protein binding; Histone; Binding site; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055887,0.0002671079,0.0003613459,0.0001560197,0.0003482349,0.0004014412,0.0004277517,0.0002394632,0.00143012],"category_scores_gemma":[0.0002129133,0.0002098027,0.0005009908,0.0001205147,0.0004231463,0.0003276939,0.0009032001,0.0005163483,0.0006065869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005270115,"about_ca_system_score_gemma":0.0005141179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109184,"about_ca_topic_score_gemma":0.001819532,"domain_scores_codex":[0.9997609,0.00001878111,0.00001018303,0.00006115309,0.00004905315,0.00009991336],"domain_scores_gemma":[0.9998735,0.00001301503,0.00002112738,0.0000092029,0.00001210984,0.00007094059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004222845,0.00005515518,0.0008616839,0.00008712635,0.00001710137,0.0001335622,0.00004622751,0.0002935216,0.9949384,0.0003322219,0.0002535097,0.002559355],"study_design_scores_gemma":[0.0002999951,0.000346529,0.02635501,0.00003531112,0.00006956107,0.0005469109,0.0002602384,0.02568075,0.9373901,0.0009920268,0.007962584,0.0000609563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935288,0.001218432,0.002764773,0.0002037943,0.00004628147,0.00002114751,0.000138516,0.0001141597,0.001964061],"genre_scores_gemma":[0.997684,0.000230471,0.001169868,0.00006808942,0.00001138265,0.00001993177,0.0001554487,0.00001635073,0.0006444511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143012,"threshold_uncertainty_score":0.004784226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648471284561513,"score_gpt":0.301481991812444,"score_spread":0.2649972789668289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}