{"id":"W2134801815","doi":"10.1021/cb900190u","title":"Synergistic Interplay between Promoter Recognition and CBP/p300 Coactivator Recruitment by FOXO3a","year":2009,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Coactivator; Transactivation; Transcription factor; Histone acetyltransferase; Biology; P300-CBP Transcription Factors; CREB-binding protein; DNA-binding protein; Cell biology; Transcription (linguistics); DNA-binding domain; Plasma protein binding; Histone; Binding site; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008561712,0.0001712625,0.000179473,0.0000296286,0.00003392546,0.00001445038,0.0001034418,0.0003340847,0.00002777992],"category_scores_gemma":[0.00007644117,0.0001555086,0.00004708958,0.00004872966,0.0001191514,0.000006385079,0.00003344158,0.0001108182,0.00001854276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002598576,"about_ca_system_score_gemma":0.00001308334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005928294,"about_ca_topic_score_gemma":7.368399e-7,"domain_scores_codex":[0.9990107,0.00006288783,0.0002289486,0.0004156634,0.00005462445,0.0002271394],"domain_scores_gemma":[0.9995812,0.00002373192,0.00007188277,0.0001786548,0.0000443452,0.0001001638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007680292,0.00004677436,0.0009147617,0.00000620174,0.00003502873,3.426637e-7,0.00001562068,4.302544e-8,0.9655557,0.00001865301,0.001312372,0.03201769],"study_design_scores_gemma":[0.0005299472,0.0004573859,0.001406236,0.00001246144,0.00002779704,0.000005739835,0.000004985808,0.000002818595,0.9796761,0.001226348,0.01644804,0.0002021171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970527,0.000234889,0.001333743,0.0006667743,0.00006570449,0.0002974008,0.0001421403,0.00002763554,0.0001790151],"genre_scores_gemma":[0.9956152,0.00004916066,0.0003230143,0.000410586,0.000165561,0.00003161571,0.003320703,0.00001231245,0.0000717789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03181557,"threshold_uncertainty_score":0.6341456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648471284561513,"score_gpt":0.301481991812444,"score_spread":0.2649972789668289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}