{"id":"W2134846340","doi":"10.1111/ijd.12724","title":"Bench to bedside: mechanistic principles of targeting the RAF kinase in melanoma","year":2014,"lang":"en","type":"review","venue":"International Journal of Dermatology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Vemurafenib; Medicine; Melanoma; Kinase; Cancer research; Metastatic melanoma; Bench to bedside; Disease; Bioinformatics; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000610115,0.0006792957,0.000767235,0.001453708,0.0003352705,0.000952567,0.0007178974,0.001243303,0.003054612],"category_scores_gemma":[0.0005167521,0.0002617734,0.0005480683,0.0008043001,0.0006290037,0.001747814,0.0006920169,0.002837087,0.0021509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005465858,"about_ca_system_score_gemma":0.0006225873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003388056,"about_ca_topic_score_gemma":0.0008540949,"domain_scores_codex":[0.9998487,0.00003010145,0.00001566993,0.00002208002,0.00006610877,0.00001734572],"domain_scores_gemma":[0.9998335,0.00007396139,0.00001566201,0.000007188591,0.00004657023,0.00002309465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001307549,0.0001592006,0.0002138585,0.01352234,0.00008153798,0.0007313881,0.0001494851,0.0007296416,0.009960923,0.02028595,0.06129336,0.8927416],"study_design_scores_gemma":[0.00001811824,0.0001137899,0.0003152255,0.001276753,0.00003528849,0.001443572,0.00004939343,0.00011771,0.001191078,0.005700114,0.9897223,0.00001661629],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002043617,0.9949166,0.000533228,0.001108786,0.0006346643,0.000009565559,0.00001533005,0.00001320591,0.002564271],"genre_scores_gemma":[0.00176107,0.9952035,0.0006048542,0.0006172064,0.0004843092,0.0000121916,0.00002184638,0.000002413095,0.001292513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003054612,"threshold_uncertainty_score":0.01021874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02647863205843515,"score_gpt":0.3195187637903334,"score_spread":0.2930401317318982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}