{"id":"W2134881603","doi":"10.1016/j.bbrc.2008.06.034","title":"FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate","year":2008,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Heart and Stroke Foundation of Canada","keywords":"Förster resonance energy transfer; Cleave; Gene isoform; Cleavage (geology); Chemistry; Biophysics; Substrate (aquarium); Protease; Caspase; Enzyme; Caspase 3; Biochemistry; Fluorescence; Molecular biology; Apoptosis; Programmed cell death; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005088591,0.0003200141,0.0004124818,0.0002271973,0.0005245578,0.0005267258,0.0009252518,0.001047829,0.00406973],"category_scores_gemma":[0.000773599,0.0002515024,0.0003328901,0.0002494548,0.0004129707,0.0007232897,0.0003262298,0.002209843,0.001474648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006969483,"about_ca_system_score_gemma":0.0003717228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006257786,"about_ca_topic_score_gemma":0.0006291775,"domain_scores_codex":[0.9996067,0.00004829943,0.0000185421,0.00009437837,0.0001337718,0.00009825027],"domain_scores_gemma":[0.9992709,0.0002973392,0.00006926552,0.0001932924,0.00009269769,0.00007664962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340049,0.00006487772,0.0003000802,0.00003244209,0.00002127411,0.0001654196,0.00003784085,0.00009047083,0.9955914,0.001279861,0.0005486368,0.001733809],"study_design_scores_gemma":[0.00002000627,0.00007257323,0.002080892,0.000004434719,0.0000117337,0.0008976335,0.0000391916,0.001200882,0.992959,0.0003271342,0.002379327,0.000007282903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652666,0.001138753,0.01513577,0.0009672249,0.0002084711,0.00002473063,0.0007712427,0.0002498806,0.01623736],"genre_scores_gemma":[0.9804341,0.0004171697,0.007599032,0.0003642715,0.00003236151,0.00005568143,0.002128421,0.00009345111,0.008875524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00406973,"threshold_uncertainty_score":0.01361454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1946244092898896,"score_gpt":0.3816447264195079,"score_spread":0.1870203171296182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}