{"id":"W2134907948","doi":"10.4049/jimmunol.1101058","title":"Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Epigenetics; Biology; Transcription factor; Cell biology; DNA methylation; Cytokine; Cellular differentiation; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005931051,0.0003016547,0.0005822776,0.0001467277,0.000441189,0.000009852087,0.0004301284,0.0005710999,0.001842143],"category_scores_gemma":[0.00003034779,0.0001941252,0.0001242566,0.00008943509,0.001445334,0.0001250855,0.0001903317,0.001038476,0.00005737511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006108537,"about_ca_system_score_gemma":0.00004114531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001485835,"about_ca_topic_score_gemma":0.0001046433,"domain_scores_codex":[0.9977128,0.0008655353,0.0006697931,0.0002416802,0.00004853122,0.0004616739],"domain_scores_gemma":[0.9987436,0.000184158,0.0005024454,0.0003862508,0.0001490805,0.00003448563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009234208,0.0001824667,0.000949819,0.00001868809,0.0004383937,0.00001171016,0.005052669,3.598249e-7,0.9899258,0.0001270962,0.0002603835,0.00210918],"study_design_scores_gemma":[0.00238051,0.001811301,0.0304722,0.00002269497,0.0002109833,0.001281252,0.001063837,3.563715e-7,0.9572743,0.001051325,0.004214541,0.0002166861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598718,0.03851213,0.00007068982,0.0002723033,0.0007170818,0.0002121889,0.00002499368,0.00002354637,0.0002953001],"genre_scores_gemma":[0.9959167,0.003070647,0.00004844808,0.0001189437,0.00003658458,0.00000269744,0.000007910375,0.00002302062,0.0007750474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03604493,"threshold_uncertainty_score":0.9990703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291494113346869,"score_gpt":0.2149758642552814,"score_spread":0.1920609231218127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}