{"id":"W2134907948","doi":"10.4049/jimmunol.1101058","title":"Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Epigenetics; Biology; Transcription factor; Cell biology; DNA methylation; Cytokine; Cellular differentiation; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007649,0.0001713229,0.0001783886,0.0003173254,0.0001746256,0.000377816,0.00008267483,0.0001771347,0.002059465],"category_scores_gemma":[0.0002236523,0.0001421448,0.0002094213,0.0002430462,0.0002219209,0.0001262405,0.0001922163,0.0002624169,0.0006486304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001026301,"about_ca_system_score_gemma":0.0001306194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003126063,"about_ca_topic_score_gemma":0.000409463,"domain_scores_codex":[0.9998451,0.00002547365,0.00001370499,0.00004344514,0.00004174211,0.00003043335],"domain_scores_gemma":[0.9997501,0.00004952983,0.00007437429,0.00006298816,0.00003996264,0.00002312798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149835,0.000009855687,0.003416296,0.00003347157,0.000009393668,0.00008530064,0.00008819272,0.00003747965,0.9917309,0.00009251716,0.0000329162,0.00434873],"study_design_scores_gemma":[0.00002007732,0.0004802772,0.06629931,0.000015761,0.00005093161,0.002359821,0.0002003867,0.0002927484,0.9202738,0.0002501205,0.009742672,0.00001404758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908966,0.002237292,0.004136642,0.00007471722,0.0000131526,0.00003063483,0.0005369553,0.00007704042,0.001997022],"genre_scores_gemma":[0.9930089,0.0009728887,0.002843146,0.00005939509,0.00001795861,0.00004145663,0.0007462168,0.00001849791,0.002291476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059465,"threshold_uncertainty_score":0.006889582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291494113346869,"score_gpt":0.2149758642552814,"score_spread":0.1920609231218127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}