{"id":"W2134922853","doi":"10.1261/rna.1229409","title":"The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing","year":2009,"lang":"en","type":"article","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Alberta; Arthritis Society; Andrew J. Semesco Foundation; Friedrich Miescher Institute for Biomedical Research","keywords":"Argonaute; Gene silencing; Biology; P-bodies; Psychological repression; Untranslated region; Genetics; Cell biology; Translation (biology); Messenger RNA; Small interfering RNA; RNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248791,0.0005375922,0.0003202772,0.0002345577,0.0002674818,0.0002342606,0.0002811082,0.0003336228,0.001971453],"category_scores_gemma":[0.000137092,0.000211082,0.0006552007,0.0002861226,0.0002874514,0.0002147243,0.000330577,0.0004821766,0.001316256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000370358,"about_ca_system_score_gemma":0.0002935852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009039677,"about_ca_topic_score_gemma":0.001144824,"domain_scores_codex":[0.9998668,0.00001409927,0.00001358196,0.00004547846,0.00003971134,0.00002025812],"domain_scores_gemma":[0.9999012,0.000009532585,0.00002939451,0.00001590701,0.00001070206,0.00003323108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007163103,0.00001001694,0.0002633482,0.00002703081,0.000007379514,0.0000748071,0.00001007346,0.00004821424,0.9985166,0.0001066794,0.00005046404,0.0008137212],"study_design_scores_gemma":[0.00002656374,0.0001110241,0.015741,0.000008766512,0.00002332795,0.0009418057,0.00002735631,0.001610802,0.9689097,0.00009432856,0.01249124,0.00001413491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806013,0.00135737,0.01395734,0.0001172657,0.00004410791,0.00005727159,0.001138673,0.0001754447,0.002551194],"genre_scores_gemma":[0.9743391,0.0005282947,0.01304091,0.0001634586,0.00001578628,0.0001092712,0.004742351,0.0000749984,0.006985692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001971453,"threshold_uncertainty_score":0.006595194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01810490728357472,"score_gpt":0.3076975436408941,"score_spread":0.2895926363573194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}