{"id":"W2134930601","doi":"10.1093/hmg/ddt610","title":"CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Congenital Ear and Nasal Anomalies","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; University of Texas Southwestern Medical Center; University of Toronto; American Heart Association","keywords":"Haploinsufficiency; Biology; Transcription factor; Cell biology; Epigenetics; Enhancer; Genetics; Embryonic stem cell; CHARGE syndrome; Bone morphogenetic protein; Histone; Gene; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007088801,0.0002193338,0.0003213075,0.0001927622,0.00004149757,0.0000466388,0.0001428937,0.00008892709,0.0002129533],"category_scores_gemma":[0.00002745477,0.0001902597,0.0000983494,0.0002753221,0.00007067306,0.00002532665,0.0001074378,0.0001244156,0.0002829678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004503412,"about_ca_system_score_gemma":0.00005371363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001054206,"about_ca_topic_score_gemma":0.0001666018,"domain_scores_codex":[0.9986508,0.00004593302,0.0002852757,0.0003614484,0.0002863751,0.0003701626],"domain_scores_gemma":[0.9990705,0.00001611923,0.00003515233,0.000414309,0.0001741625,0.0002897911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001049457,0.0001314995,0.01536399,0.0000620418,0.0001307615,0.0003741719,0.000434201,0.0002064611,0.9674936,0.0001142359,0.0003255518,0.01525855],"study_design_scores_gemma":[0.001095778,0.001050743,0.7767258,0.0001254966,0.0001305252,0.00009502516,0.00008776282,0.00009310782,0.2176214,0.0002557138,0.002333263,0.0003854115],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926833,0.001119124,0.0004871796,0.0004906047,0.00004431839,0.0006709525,0.000002630496,0.0000361464,0.004465782],"genre_scores_gemma":[0.9931825,0.00002298999,0.004075448,0.0009528454,0.00007143956,0.00005485244,0.00001398931,0.00005576926,0.001570097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7613618,"threshold_uncertainty_score":0.7758567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008525727489842996,"score_gpt":0.2445173552035195,"score_spread":0.2359916277136765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}