{"id":"W2134966461","doi":"10.1016/s1473-3099(14)70937-5","title":"Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial","year":2014,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Bill and Melinda Gates Foundation","keywords":"Emtricitabine; Medicine; Pre-exposure prophylaxis; Placebo; Discontinuation; Tenofovir; Lamivudine; Internal medicine; Pharmacology; Viral load; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy; Men who have sex with men; Virus; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004419276,0.002186058,0.006716945,0.0007464949,0.0005508447,0.001510585,0.001557099,0.002793768,0.007433075],"category_scores_gemma":[0.005033954,0.0009285335,0.004605214,0.0007788163,0.001227511,0.002103268,0.0004961676,0.004552737,0.001250145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001024926,"about_ca_system_score_gemma":0.00119531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143484,"about_ca_topic_score_gemma":0.004106999,"domain_scores_codex":[0.9978898,0.001150854,0.000244651,0.0002866298,0.0002103036,0.0002176534],"domain_scores_gemma":[0.9978486,0.001004446,0.0004747099,0.0001971311,0.0001578627,0.0003172471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9689897,0.001478661,0.0002161725,0.002317905,0.003191102,0.00002756783,0.00007635119,0.0002049028,0.001520962,0.0001170612,0.0007166244,0.02114291],"study_design_scores_gemma":[0.9775441,0.01858762,0.0008118667,0.0001529797,0.001610445,0.0000354353,0.00002019594,0.0001852841,0.000230524,0.0001562012,0.000644592,0.00002073408],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9042338,0.06839795,0.003589421,0.002080864,0.003577465,0.007665552,0.004300653,0.0004978823,0.005656397],"genre_scores_gemma":[0.9597004,0.02159088,0.004323512,0.001768387,0.0009512274,0.004695744,0.001985385,0.0001111,0.004873351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007433075,"threshold_uncertainty_score":0.02486616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1001773660239104,"score_gpt":0.3965450898947543,"score_spread":0.2963677238708439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}