{"id":"W2134992655","doi":"10.1124/dmd.105.007740","title":"MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"ABCC1; Transmembrane domain; Amino acid; Biochemistry; Point mutation; Chemistry; Mutation; Transport protein; Transmembrane protein; Biology; Stereochemistry; Molecular biology; ATP-binding cassette transporter; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004472896,0.0002521322,0.0007661447,0.0004111405,0.0001035478,0.00001922961,0.00006083041,0.0001084219,0.00005045049],"category_scores_gemma":[0.00001552481,0.000196945,0.000177977,0.0005936685,0.0002140631,0.0001649782,0.000005390259,0.0001313953,5.963713e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001557703,"about_ca_system_score_gemma":0.00003264608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003483493,"about_ca_topic_score_gemma":0.00132156,"domain_scores_codex":[0.9981618,0.0001365855,0.0006046855,0.0003981066,0.0005078334,0.0001910089],"domain_scores_gemma":[0.9991695,0.00007032713,0.0002951325,0.0002144634,0.0001497094,0.0001009055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00767622,0.0005595967,0.00855783,0.001480308,0.0006661647,0.00003568024,0.001290497,0.0001264399,0.9708436,0.008297689,0.00002927629,0.0004366563],"study_design_scores_gemma":[0.001846636,0.0001024233,0.4496324,0.0002429678,0.001625932,0.000001761769,0.0001218366,0.0001696852,0.5457554,0.0003253702,0.00004137904,0.0001341204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942642,0.002843235,0.0005180466,0.0001282686,0.00004346677,0.0006451776,0.0007751296,0.00004044603,0.000742037],"genre_scores_gemma":[0.9967555,0.00008304212,0.000829161,0.00001777838,0.00007334082,0.00003075341,0.001369068,0.00001881963,0.0008225579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4410746,"threshold_uncertainty_score":0.8031182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004485723273823318,"score_gpt":0.2156978458858467,"score_spread":0.2112121226120234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}