{"id":"W2134992655","doi":"10.1124/dmd.105.007740","title":"MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"ABCC1; Transmembrane domain; Amino acid; Biochemistry; Point mutation; Chemistry; Mutation; Transport protein; Transmembrane protein; Biology; Stereochemistry; Molecular biology; ATP-binding cassette transporter; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004557315,0.0007543629,0.0006051216,0.0003370621,0.0004072517,0.000329756,0.0005850186,0.0008987363,0.002761163],"category_scores_gemma":[0.0009131439,0.0002643444,0.0006821498,0.0003750642,0.0006896921,0.0002324161,0.0003529058,0.0008577523,0.0008648945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003870451,"about_ca_system_score_gemma":0.0003506955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270224,"about_ca_topic_score_gemma":0.001473263,"domain_scores_codex":[0.9995885,0.0001581958,0.00006211784,0.00005310267,0.00007911656,0.00005897065],"domain_scores_gemma":[0.9990207,0.0004969367,0.0001984562,0.00005603922,0.00008866494,0.0001392394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001611316,0.0001939175,0.001269687,0.0001311997,0.0000575147,0.001623733,0.00008973416,0.0009031272,0.991567,0.0003319232,0.000112137,0.002108737],"study_design_scores_gemma":[0.0002295687,0.001202348,0.01217987,0.00005784413,0.0002567563,0.00498533,0.0001427895,0.005626969,0.9727192,0.0002041149,0.002337335,0.00005779494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959993,0.000407052,0.001842649,0.0001373641,0.00004990357,0.00006781127,0.0003949334,0.00003970734,0.001061236],"genre_scores_gemma":[0.9973994,0.0002200486,0.001468492,0.00009028815,0.00001452829,0.00002315879,0.0003124606,0.00003418214,0.0004374776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002761163,"threshold_uncertainty_score":0.009236991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004485723273823318,"score_gpt":0.2156978458858467,"score_spread":0.2112121226120234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}