{"id":"W2135002443","doi":"10.1038/mt.2014.194","title":"First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University Health Network","funders":"National Center for Advancing Translational Sciences; National Cancer Institute","keywords":"Oncolytic virus; Vaccinia; Virus; Virology; Virulence; Viral replication; Medicine; Biology; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00358519,0.001377355,0.001671223,0.0004142899,0.0005775435,0.000847091,0.0008035401,0.000787985,0.001618097],"category_scores_gemma":[0.001244121,0.0005411428,0.0009268881,0.0002817237,0.001209783,0.0009888691,0.0002668277,0.002145921,0.0005767618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008591634,"about_ca_system_score_gemma":0.001067603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008314427,"about_ca_topic_score_gemma":0.0007013859,"domain_scores_codex":[0.9988841,0.0005905867,0.000046291,0.0001745569,0.00009365113,0.000210813],"domain_scores_gemma":[0.9987792,0.0002451963,0.0001764835,0.0002478465,0.0001147828,0.0004364956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05734932,0.07734894,0.02264671,0.000788431,0.0008463686,0.00200592,0.001333858,0.00341754,0.7221626,0.001440291,0.002717153,0.107943],"study_design_scores_gemma":[0.006552858,0.8046465,0.0111495,0.00002951677,0.0004950548,0.002131919,0.0001243006,0.001757163,0.1636155,0.0003621584,0.009094881,0.00004047992],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921255,0.001811054,0.003417864,0.0001646878,0.00006204512,0.00072475,0.0003352094,0.00008510816,0.001273805],"genre_scores_gemma":[0.9936208,0.001184364,0.001955528,0.0002255464,0.0001033704,0.0003862661,0.0007327278,0.00005724878,0.001734076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00358519,"threshold_uncertainty_score":0.01896054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722536157705793,"score_gpt":0.3013002170472189,"score_spread":0.284074855470161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}