{"id":"W2135032572","doi":"10.1039/c5nr02283e","title":"DNA topology influences molecular machine lifetime in human serum","year":2015,"lang":"en","type":"article","venue":"Nanoscale","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; Boise State University; W. M. Keck Foundation","keywords":"DNA; Topology (electrical circuits); Human blood; Computer science; Materials science; Nanotechnology; Biological system; Computational biology; Engineering; Biology; Genetics; Electrical engineering; Physiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000431692,0.0001342792,0.0001427089,0.0002327685,0.0001796586,0.0005952771,0.0001625153,0.0002951397,0.001094058],"category_scores_gemma":[0.002628154,0.0001307513,0.0001101678,0.0001415715,0.0003596615,0.0004532574,0.0002059334,0.0002622313,0.0002912792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003606107,"about_ca_system_score_gemma":0.0002596494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009025245,"about_ca_topic_score_gemma":0.0004434251,"domain_scores_codex":[0.9998043,0.00006398276,0.00001125952,0.00004275161,0.00003495863,0.00004279191],"domain_scores_gemma":[0.9991388,0.000490443,0.0001477171,0.00003946444,0.00008448518,0.0000990781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007418333,0.00003643118,0.003280261,0.00005105276,0.00001187132,0.0001088369,0.0002163885,0.001254929,0.9882626,0.000802667,0.00009508141,0.005138125],"study_design_scores_gemma":[0.00002617964,0.0005932657,0.01003988,0.00001152472,0.00002626592,0.0003424683,0.000173562,0.01384332,0.9730147,0.0006908927,0.001212165,0.00002575605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978365,0.0004703963,0.001069636,0.00006088864,0.000006639417,0.00000395508,0.00005354528,0.00002635514,0.0004720965],"genre_scores_gemma":[0.9994529,0.0001062037,0.0001841252,0.00001836914,0.000001509388,0.000002568519,0.00003762082,0.000006900124,0.000189762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094058,"threshold_uncertainty_score":0.003660023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036628025498982,"score_gpt":0.2905435289675082,"score_spread":0.2801772487125184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}