{"id":"W2135033441","doi":"10.1093/toxsci/kfs015","title":"Effects of Tris(1,3-dichloro-2-propyl) phosphate and Tris(1-chloropropyl) phosphate on Cytotoxicity and mRNA Expression in Primary Cultures of Avian Hepatocytes and Neuronal Cells","year":2012,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Tris; Chemistry; Messenger RNA; Downregulation and upregulation; Biochemistry; Gene expression; Cytotoxicity; Molecular biology; Biology; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104999,0.0002765259,0.0004744619,0.00006578771,0.00018494,0.00003636642,0.000303958,0.0001725127,0.0002602933],"category_scores_gemma":[0.0003387553,0.000172709,0.00003802011,0.00041417,0.00208747,0.0005098046,0.0004392138,0.0002239575,0.000007766179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008315662,"about_ca_system_score_gemma":0.00002189724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006900317,"about_ca_topic_score_gemma":0.00001044585,"domain_scores_codex":[0.997615,0.0002152933,0.0004350042,0.000539918,0.0005844109,0.0006103886],"domain_scores_gemma":[0.998726,0.0005131215,0.0002716553,0.000139731,0.000003177353,0.0003462875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001943123,0.0003754262,0.1066746,0.00003503791,0.000003706622,0.000006806457,0.0004704366,0.000008696119,0.8702629,0.00002238434,0.00003062653,0.02191499],"study_design_scores_gemma":[0.0004795981,0.0007341941,0.5007969,0.00003561655,0.000007687592,0.000005819411,0.00003248019,0.0000679942,0.4975514,0.0001411098,0.00002570357,0.0001214764],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970718,0.001421036,0.000008759497,0.000113051,0.00009416627,0.0005740261,0.00001881097,0.00002588137,0.0006724827],"genre_scores_gemma":[0.9982027,0.000678249,0.0007287476,0.00030631,0.00002324414,0.00001122231,2.374509e-7,0.000008635795,0.0000406506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3941223,"threshold_uncertainty_score":0.7691369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226345816292361,"score_gpt":0.2425912696695874,"score_spread":0.2303278115066638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}