{"id":"W2135057615","doi":"10.3109/10428190903585286","title":"A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study","year":2010,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Sorafenib; Internal medicine; Myeloid leukemia; Refractory (planetary science); Regimen; Myelodysplastic syndromes; Oncology; Population; Phases of clinical research; Chemotherapy; Leukemia; Clinical trial; Gastroenterology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001993876,0.001770714,0.003006299,0.0004813037,0.0005333318,0.001089811,0.0009279816,0.001556571,0.007660537],"category_scores_gemma":[0.001693868,0.00079745,0.001619276,0.0004722364,0.001216942,0.001109784,0.0004537427,0.003050254,0.001149909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001124006,"about_ca_system_score_gemma":0.002060205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374478,"about_ca_topic_score_gemma":0.003687259,"domain_scores_codex":[0.9993548,0.0003068978,0.00003193221,0.0001198876,0.00005702454,0.0001294918],"domain_scores_gemma":[0.998778,0.0001984077,0.0002181494,0.0001024089,0.00006835409,0.0006346891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9642474,0.01605587,0.0008256792,0.0003014599,0.0005544025,0.00005887482,0.0000533259,0.0004248911,0.002899778,0.0001795592,0.001473581,0.01292523],"study_design_scores_gemma":[0.9560586,0.04172472,0.001149153,0.00000822821,0.0001183338,0.0000247754,0.00001312744,0.0002042591,0.0001232869,0.0000943221,0.0004727807,0.000008513594],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828302,0.002543389,0.0007850064,0.001049763,0.0005479261,0.007843942,0.001753862,0.000108932,0.002536892],"genre_scores_gemma":[0.9721182,0.002405369,0.002512841,0.001911219,0.0005707268,0.01288679,0.002839269,0.00003556187,0.004720123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007660537,"threshold_uncertainty_score":0.02562708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05373140772422855,"score_gpt":0.3961122256343599,"score_spread":0.3423808179101313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}