{"id":"W2135057615","doi":"10.3109/10428190903585286","title":"A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study","year":2010,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Sorafenib; Internal medicine; Myeloid leukemia; Refractory (planetary science); Regimen; Myelodysplastic syndromes; Oncology; Population; Phases of clinical research; Chemotherapy; Leukemia; Clinical trial; Gastroenterology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.01188042,0.001035618,0.0069972,0.000947809,0.0002189586,0.00004944733,0.0007265111,0.0007920949,0.00008734],"category_scores_gemma":[0.007557862,0.0006938462,0.0004518484,0.001427967,0.002927361,0.0004158564,0.0005460395,0.0009545447,0.000001733169],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003701078,"about_ca_system_score_gemma":0.0360927,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0944052,"about_ca_topic_score_gemma":0.1151829,"domain_scores_codex":[0.9856744,0.002859979,0.006293651,0.001742949,0.002366148,0.001062823],"domain_scores_gemma":[0.988053,0.006163411,0.002608401,0.001085978,0.001220137,0.0008690839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3281242,0.007929659,0.6348251,0.0004605114,0.004577837,0.0009484582,0.0008066331,0.00007178038,0.0006364883,0.0002691861,0.0001745695,0.02117554],"study_design_scores_gemma":[0.5296668,0.007538257,0.4564793,0.0003557544,0.001684819,0.0001857647,0.0007487512,0.002565817,0.0001433357,0.00008244911,0.00005281821,0.0004960881],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913209,0.000288819,0.00004247433,0.00005773695,0.0008938775,0.006941363,0.0003153114,0.00005402049,0.00008547151],"genre_scores_gemma":[0.9971207,0.0004517677,0.001035335,0.0001789779,0.0002428711,0.0006045177,0.0001134786,0.0001081191,0.0001442659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2015426,"threshold_uncertainty_score":0.9997861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05373140772422855,"score_gpt":0.3961122256343599,"score_spread":0.3423808179101313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}