{"id":"W2135059873","doi":"10.1093/nar/gkj400","title":"TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters","year":2006,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Associazione Italiana per la Ricerca sul Cancro; Regione Campania; Ministero dell’Istruzione, dell’Università e della Ricerca; Queen's University","keywords":"Psychological repression; Biology; Promoter; Acetyltransferase; Chromatin immunoprecipitation; Histone acetyltransferase; PCAF; Transcription (linguistics); Histone deacetylase 2; Histone; Histone Acetyltransferases; Demethylation; Enhancer; Transcription factor; Molecular biology; Gene; DNA methylation; Gene expression; Genetics; Acetylation; Histone deacetylase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001123972,0.00008202262,0.0001277553,0.00006902049,0.00009948748,0.00001269776,0.0001235734,0.0001394948,0.00001473159],"category_scores_gemma":[0.000207933,0.00005522426,0.00003925221,0.0001808757,0.0002322934,0.000006364111,0.00003119291,0.0001381407,4.030122e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002175697,"about_ca_system_score_gemma":0.00006451832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629877,"about_ca_topic_score_gemma":0.00007438834,"domain_scores_codex":[0.998624,0.000258572,0.0002299683,0.0002181289,0.000494371,0.0001749302],"domain_scores_gemma":[0.9991849,0.0001243765,0.00008770418,0.0002068863,0.0003641126,0.00003200939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001809851,0.0000704243,0.0156075,0.00002707085,0.00003800897,3.467381e-7,0.0001532318,0.00006387525,0.9822916,0.0001213543,0.0001436615,0.001301884],"study_design_scores_gemma":[0.0005025266,0.0004460273,0.09299886,0.00002880967,0.00001795027,7.09925e-7,0.00007683736,0.00006296842,0.9036702,0.000480021,0.00165007,0.0000650518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953473,0.002770693,0.0005425931,0.0004826689,0.00002024835,0.0002265403,0.00002821392,0.00000439309,0.000577331],"genre_scores_gemma":[0.9980277,0.0007665014,0.0006223539,0.000005004537,0.00005385496,0.00001390373,0.0001152393,0.00001430764,0.0003811512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0786215,"threshold_uncertainty_score":0.225198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703926048750444,"score_gpt":0.3069045684001557,"score_spread":0.2898653079126512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}