{"id":"W2135073823","doi":"10.1002/iub.1150","title":"Phenylalanine hydroxylase: Function, structure, and regulation","year":2013,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"Novo Nordisk Fonden; Norges Forskningsråd; Novo Nordisk","keywords":"Phenylalanine hydroxylase; Tetrahydrobiopterin; Phenylalanine; Catabolism; Biochemistry; Cofactor; Enzyme; Chemistry; Function (biology); Amino acid; Biology; Anabolism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008196752,0.0003333303,0.0005820601,0.00006326706,0.00006207315,0.00004644053,0.0001509177,0.000394105,0.0003598758],"category_scores_gemma":[0.00008115869,0.00026988,0.0001360337,0.00009843324,0.00006708231,0.000003189903,0.0001034112,0.0001111491,0.00005349993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002059897,"about_ca_system_score_gemma":0.0001501633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001047871,"about_ca_topic_score_gemma":0.00000564489,"domain_scores_codex":[0.9987354,0.00009193522,0.0003496318,0.0004819313,0.0001311615,0.0002099201],"domain_scores_gemma":[0.9991198,0.000009948315,0.0002030615,0.0004594678,0.00005460414,0.0001530896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007270224,0.0000145161,0.00001764504,0.001823003,0.0001932475,3.029064e-7,0.000004630147,0.000003145546,0.0001623915,0.0001931612,0.03434039,0.9632403],"study_design_scores_gemma":[0.0002018712,0.00004742467,0.0001152553,0.0001738303,0.0003227298,0.00001216793,0.000003119641,0.000003431558,0.00003494715,0.000181267,0.9986095,0.0002944635],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004566609,0.9975135,0.0002659187,0.00001271211,0.0004251042,0.0004574377,0.00008015068,0.00001407734,0.0007744651],"genre_scores_gemma":[0.000256865,0.9932086,0.0002187533,0.0001656487,0.0008719549,0.00005097815,0.001446615,0.00005288217,0.003727667],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9642691,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540373252290758,"score_gpt":0.266232764399349,"score_spread":0.2508290318764414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}