{"id":"W2135109846","doi":"10.1084/jem.191.10.1709","title":"Apoptotic Protease Activating Factor 1 (Apaf-1)–Independent Cell Death Suppression by Bcl-2","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences","keywords":"Programmed cell death; Staurosporine; Apoptosis; Biology; Propidium iodide; Caspase; Molecular biology; Cell biology; Bcl-2 family; Genetics; Signal transduction; Protein kinase C","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231173,0.0001360118,0.0001543285,0.00002598821,0.0001085193,0.000007505265,0.0001757605,0.00007588261,0.000891311],"category_scores_gemma":[0.0000162858,0.00007405459,0.00005949038,0.0000367676,0.00004931535,0.00000872647,0.00003250622,0.0001350127,0.000004035862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002757057,"about_ca_system_score_gemma":0.00002343246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001960676,"about_ca_topic_score_gemma":2.279255e-7,"domain_scores_codex":[0.9990363,0.00009531451,0.0003040094,0.0001092409,0.0003030781,0.0001520294],"domain_scores_gemma":[0.9994581,0.00001567644,0.0002111165,0.0001661015,0.00003919502,0.0001097477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003299107,0.0001219202,0.000023741,0.000005918038,0.00001883739,0.000002941405,0.0003896861,0.00002904916,0.993642,0.000002830319,0.001480026,0.00395314],"study_design_scores_gemma":[0.001348687,0.001272927,0.0001976432,0.00007209269,0.00001711081,0.00009925963,0.000712283,0.00008287688,0.9891104,0.0000155818,0.006982632,0.00008847285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929072,0.005004317,0.0004213229,0.0002319859,0.0001935543,0.0002000258,0.000002794811,0.000003299906,0.001035538],"genre_scores_gemma":[0.9969024,0.0004857952,0.0001653493,0.000141624,0.0004532532,0.000003086198,0.00001500541,0.00001703095,0.001816436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005502606,"threshold_uncertainty_score":0.9759231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169084371969607,"score_gpt":0.2679852730161653,"score_spread":0.2562944292964692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}