{"id":"W2135131077","doi":"10.1186/bcr3398","title":"Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer","year":2013,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council; Canadian Institutes of Health Research","keywords":"Unfolded protein response; Biology; Cancer research; PRNP; XBP1; Gene silencing; Molecular biology; Gene expression; Endoplasmic reticulum; Gene; Cell biology; RNA splicing; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152383,0.0001927941,0.0002420602,0.0003044478,0.0001853722,0.0002684675,0.0000911395,0.0002219061,0.001990459],"category_scores_gemma":[0.00009861986,0.0001159558,0.000238385,0.0003168339,0.0001397753,0.00008840723,0.0001550873,0.0004819321,0.0006965788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089996,"about_ca_system_score_gemma":0.0001530718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003951781,"about_ca_topic_score_gemma":0.0005396529,"domain_scores_codex":[0.9998755,0.00001498984,0.00001147874,0.00002487074,0.00004338647,0.00002970008],"domain_scores_gemma":[0.9999052,0.00001972476,0.00002163987,0.00001207208,0.00002174296,0.00001961631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435609,0.00002806378,0.0006505107,0.00008691344,0.000007430581,0.0001203956,0.0000222614,0.00002016515,0.9971256,0.00002955547,0.0001973761,0.001568099],"study_design_scores_gemma":[0.00005626533,0.0007743647,0.07929557,0.00003175216,0.00007706284,0.001869615,0.0001998054,0.001008914,0.9038994,0.0001385588,0.01263696,0.00001172831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885697,0.005191613,0.00184577,0.0002414614,0.00008910053,0.00004492055,0.001642024,0.0001495352,0.002225927],"genre_scores_gemma":[0.9846541,0.003309664,0.002687165,0.0002071338,0.00004121578,0.00008523371,0.003851521,0.00002417254,0.005139888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990459,"threshold_uncertainty_score":0.006658792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187036740032876,"score_gpt":0.3292371428123073,"score_spread":0.3073667754119785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}