{"id":"W2135134352","doi":"10.3109/10731190009119782","title":"Gene Therapy for Hemophilia","year":2000,"lang":"en","type":"review","venue":"Artificial Cells Blood Substitutes and Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Genetic enhancement; Factor IX; Medicine; Cell therapy; Gene delivery; Ex vivo; Gene; Coagulation; In vivo; Bioinformatics; Immunology; Biology; Internal medicine; Biotechnology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002597341,0.0005410174,0.0009764374,0.0002348389,0.0002292955,0.00005825149,0.0005571897,0.00160772,0.00004511808],"category_scores_gemma":[0.0000246827,0.0004561414,0.0004144939,0.0002605711,0.0004553958,0.000003460148,0.000134761,0.0003389347,0.00004315778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000112314,"about_ca_system_score_gemma":0.0002505983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001140947,"about_ca_topic_score_gemma":0.00008122536,"domain_scores_codex":[0.997613,0.00008868437,0.0005245387,0.001001749,0.0001281694,0.0006438947],"domain_scores_gemma":[0.998855,0.00004234348,0.0001588554,0.0007773638,0.00005371454,0.0001127358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003587655,0.0001702418,2.658559e-7,0.0004759125,0.0003133893,0.00001124054,0.000003312573,9.970436e-7,0.09988046,0.0001961325,0.0002187486,0.8983706],"study_design_scores_gemma":[0.0002612456,0.001804309,3.359082e-8,0.00008635342,0.0001366244,0.00003596205,0.000002028855,0.000001677864,0.3895275,0.0002548664,0.6075652,0.0003242595],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02404937,0.9738123,0.00002668111,0.0001524828,0.0002094132,0.001419684,0.000231456,0.00006368213,0.00003490987],"genre_scores_gemma":[0.0004078262,0.9973727,0.0004339355,0.0001162458,0.0004747335,0.0002693344,0.0005198606,0.00009487251,0.0003104647],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8980463,"threshold_uncertainty_score":0.9997891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03805506870527564,"score_gpt":0.3117091535483967,"score_spread":0.2736540848431211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}