{"id":"W2135134352","doi":"10.3109/10731190009119782","title":"Gene Therapy for Hemophilia","year":2000,"lang":"en","type":"review","venue":"Artificial Cells Blood Substitutes and Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Genetic enhancement; Factor IX; Medicine; Cell therapy; Gene delivery; Ex vivo; Gene; Coagulation; In vivo; Bioinformatics; Immunology; Biology; Internal medicine; Biotechnology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005528827,0.001181854,0.00102741,0.002528224,0.000432497,0.0008181581,0.0007556727,0.001612532,0.004822057],"category_scores_gemma":[0.0004451132,0.0002405995,0.0004419955,0.002266459,0.0008112785,0.001307977,0.0006472261,0.002283148,0.004586175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007605152,"about_ca_system_score_gemma":0.0005179825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107764,"about_ca_topic_score_gemma":0.001774225,"domain_scores_codex":[0.9997792,0.00004207812,0.00001957292,0.000048631,0.00009297075,0.00001767443],"domain_scores_gemma":[0.999873,0.00005938854,0.00001933779,0.000009072462,0.00002526922,0.0000139579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006650967,0.0001273067,0.0001542034,0.004713502,0.00005762314,0.0004946805,0.0001263228,0.0004725746,0.009945412,0.008537202,0.04484423,0.9304603],"study_design_scores_gemma":[0.00003085885,0.00009455741,0.0004330093,0.0008544571,0.00003099384,0.002576751,0.00003128771,0.0001006345,0.002160829,0.002430798,0.9912407,0.00001524076],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003190384,0.9932455,0.0007090739,0.0003179403,0.0003882099,0.00001736575,0.00002063942,0.00002384976,0.004958231],"genre_scores_gemma":[0.00214706,0.9891196,0.001043474,0.0005931347,0.0002132193,0.00003131777,0.00006113678,0.000008656052,0.00678227],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004822057,"threshold_uncertainty_score":0.01613134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03805506870527564,"score_gpt":0.3117091535483967,"score_spread":0.2736540848431211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}