{"id":"W2135141635","doi":"10.1152/ajplung.00324.2015","title":"The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia","year":2015,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis; Mucociliary clearance; Phosphodiesterase; Primary ciliary dyskinesia; Potentiator; Cilium; Respiratory epithelium; Cystic fibrosis transmembrane conductance regulator; Medicine; Stimulation; Phosphodiesterase 3; Pharmacology; Biology; Internal medicine; Endocrinology; Lung; Cell biology; Bronchiectasis; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002953556,0.0004968331,0.0005409314,0.0003674962,0.0002997483,0.0003189207,0.0002783063,0.0004299077,0.001488803],"category_scores_gemma":[0.0001515763,0.0002311441,0.0006463382,0.000243557,0.0002529583,0.0002048002,0.0003275,0.00105127,0.0004855283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005074252,"about_ca_system_score_gemma":0.0003405404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001772295,"about_ca_topic_score_gemma":0.00332248,"domain_scores_codex":[0.9996353,0.00007645721,0.0000425762,0.0000593077,0.0001029143,0.00008336078],"domain_scores_gemma":[0.9998562,0.00004876963,0.00001823476,0.00002142315,0.00001259009,0.00004268172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002373228,0.00006024318,0.00008655424,0.00005646799,0.000006078818,0.00004691949,0.00001378693,0.00002898283,0.9979479,0.00003531241,0.0001047582,0.001375702],"study_design_scores_gemma":[0.00007094524,0.001061709,0.004012483,0.00001050034,0.00002643958,0.0001471182,0.00002142417,0.0004963328,0.9924224,0.00001959424,0.001705945,0.000005105169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801058,0.01054616,0.002764391,0.0005056755,0.0002863615,0.00009569232,0.001127781,0.0001469425,0.004421081],"genre_scores_gemma":[0.9868023,0.003404579,0.004296867,0.0002151794,0.00008513096,0.0001313884,0.001296101,0.00002811157,0.003740206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772295,"threshold_uncertainty_score":0.004980564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005480230285370125,"score_gpt":0.2672218422910005,"score_spread":0.2617416120056304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}