{"id":"W2135174104","doi":"10.1161/circresaha.117.306666","title":"Differential Role of an NF-κB Transcriptional Response Element in Endothelial Versus Intimal Cell VCAM-1 Expression","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"Chromatin immunoprecipitation; Molecular biology; Biology; Promoter; Mutant; Wild type; Transfection; Transcription factor; NFKB1; Gene expression; Endothelium; Cell biology; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001230448,0.0001032297,0.0001140285,0.0002022818,0.00005648766,0.00002538572,0.0002183545,0.0001524465,0.0001256322],"category_scores_gemma":[0.0002060852,0.0001078591,0.00005554454,0.0001508449,0.00009711524,0.00001237889,0.00008071072,0.0001809925,0.00001655184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006958674,"about_ca_system_score_gemma":0.0003037389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006123693,"about_ca_topic_score_gemma":0.00003265824,"domain_scores_codex":[0.9977253,0.0007080995,0.0002688591,0.0003416402,0.0006671839,0.0002888828],"domain_scores_gemma":[0.9991536,0.00005142905,0.00005226655,0.0003133581,0.0002873276,0.0001420766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006764547,0.0002426166,0.002233593,0.00001109287,0.000006902246,0.000002849271,0.0002892023,0.002182904,0.9875063,0.00009981493,0.00005594288,0.0006042767],"study_design_scores_gemma":[0.003303583,0.0007201772,0.009949815,0.00001429585,0.000003451348,0.000001314466,0.0003883586,0.00310208,0.9810812,0.0002559877,0.001065371,0.0001143299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979197,0.0001016605,0.0008253909,0.00002773229,0.0001291521,0.0002589147,0.00003428496,0.000007921431,0.000695259],"genre_scores_gemma":[0.9990896,0.00000455384,0.0003533449,0.000005320937,0.0001869413,0.00003735281,0.0002348438,0.00001961692,0.00006845487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007716221,"threshold_uncertainty_score":0.4398366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08515156725775935,"score_gpt":0.3588838091817216,"score_spread":0.2737322419239622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}