{"id":"W2135174104","doi":"10.1161/circresaha.117.306666","title":"Differential Role of an NF-κB Transcriptional Response Element in Endothelial Versus Intimal Cell VCAM-1 Expression","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"Chromatin immunoprecipitation; Molecular biology; Biology; Promoter; Mutant; Wild type; Transfection; Transcription factor; NFKB1; Gene expression; Endothelium; Cell biology; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002684954,0.0002760639,0.0001475264,0.0002243133,0.0001637541,0.0003498724,0.0002318692,0.0002784241,0.001332922],"category_scores_gemma":[0.0002638746,0.0001230918,0.0001522325,0.0001111147,0.0003447378,0.0001832081,0.0001927464,0.0004979498,0.0002887207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219408,"about_ca_system_score_gemma":0.0002525941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002220246,"about_ca_topic_score_gemma":0.0003103367,"domain_scores_codex":[0.9997732,0.00002620509,0.00002001122,0.00006967111,0.00006626214,0.00004460618],"domain_scores_gemma":[0.9997751,0.00005352068,0.00007134481,0.00003173261,0.00002247901,0.0000457746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000066717,0.00001819941,0.0004374556,0.00003326587,0.000001492631,0.00002474027,0.00001125081,0.00001943984,0.9985862,0.000135948,0.00000978415,0.0006554794],"study_design_scores_gemma":[0.00001288924,0.0001534694,0.005709853,0.0000129462,0.00001084013,0.000359638,0.00002175687,0.000459273,0.9920814,0.0000844785,0.001089715,0.000003715473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895524,0.001454786,0.00765757,0.0001115437,0.0000368848,0.00003408919,0.0003537174,0.00006883264,0.0007301099],"genre_scores_gemma":[0.9934707,0.0004142816,0.00458741,0.000035111,0.000009814893,0.00004876246,0.000403559,0.00001258645,0.001017781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332922,"threshold_uncertainty_score":0.004459023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08515156725775935,"score_gpt":0.3588838091817216,"score_spread":0.2737322419239622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}