{"id":"W2135197754","doi":"10.1186/gb-2007-8-5-r95","title":"Unequal evolutionary conservation of human protein interactions in interologous networks","year":2007,"lang":"en","type":"article","venue":"Genome biology","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Genomics; Ontario Genomics Institute; Genome Canada; U.S. Department of Defense","keywords":"Biology; Interactome; Conserved sequence; Protein–protein interaction; Computational biology; Genetics; Gene; Interaction network; Evolutionary biology; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003913183,0.0001116427,0.0001565963,0.0001018548,0.0000462575,0.000003499284,0.00015203,0.0001830608,0.00002710317],"category_scores_gemma":[0.00002028526,0.0001111509,0.00005582046,0.0001028304,0.0001385186,0.000003581467,0.0001128997,0.0001456854,0.000004361221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003006369,"about_ca_system_score_gemma":0.000030586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009274352,"about_ca_topic_score_gemma":0.0005709575,"domain_scores_codex":[0.9990135,0.00004950068,0.0004553819,0.0001831539,0.00003017271,0.0002682664],"domain_scores_gemma":[0.9995046,0.00001603059,0.0001691839,0.0002072528,0.00006172484,0.00004119395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000264976,0.0001178705,0.03034947,0.00001886618,0.0000631177,0.000002421464,0.0001252552,0.0006991367,0.9591342,0.004806216,0.0004073966,0.004011036],"study_design_scores_gemma":[0.008133266,0.008103659,0.7091694,0.0001962203,0.00008973743,0.0001775869,0.001355003,0.01244512,0.05083372,0.03016743,0.17681,0.002518815],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947672,0.0004875297,0.05011781,0.00008507483,0.0002259927,0.0002425217,0.00001339697,0.000007647131,0.00114804],"genre_scores_gemma":[0.9982252,0.00001859707,0.0006551811,0.000231291,0.0002050866,0.00001574854,0.0004484506,0.000009432796,0.0001910163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9083005,"threshold_uncertainty_score":0.4532604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368962455971215,"score_gpt":0.2703533298249862,"score_spread":0.256663705265274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}