{"id":"W2135227577","doi":"10.1002/em.10197","title":"DNA end sequestration by DNA‐dependent protein kinase and end joining of sterically constrained substrates in whole‐cell extracts","year":2003,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"Wortmannin; DNA; Biology; Xenopus; DNA footprinting; Molecular biology; Non-homologous end joining; DNA damage; Cell biology; Biochemistry; Kinase; DNA-binding protein; Gene; Phosphatidylinositol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115993,0.0005332238,0.0002962476,0.0001598624,0.0001829518,0.0003361789,0.0002349581,0.0002435466,0.001328571],"category_scores_gemma":[0.0001903438,0.0003193884,0.0004198278,0.0002611876,0.0001707887,0.0002756681,0.0001831389,0.0005077123,0.0005254017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927076,"about_ca_system_score_gemma":0.0001842499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003459369,"about_ca_topic_score_gemma":0.0008786366,"domain_scores_codex":[0.9998254,0.00004504335,0.00001908127,0.00004797832,0.00003707982,0.00002541762],"domain_scores_gemma":[0.9998705,0.00003641571,0.0000336269,0.00002721736,0.00001187425,0.00002023008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005148318,0.000008220532,0.00008982621,0.00004115781,0.000007845245,0.00002437768,0.00001087401,0.00007983352,0.9991697,0.00004253965,0.00000840407,0.0004657926],"study_design_scores_gemma":[0.00000980778,0.0001295998,0.002461408,0.000004997352,0.00001317803,0.0001834381,0.00001403977,0.0006037954,0.99522,0.00002242415,0.001333113,0.000004101436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848577,0.002394833,0.01091122,0.00003882327,0.00002436443,0.00005123103,0.0004549861,0.00006557863,0.001201163],"genre_scores_gemma":[0.9742716,0.001771274,0.0155698,0.00003363554,0.00001467962,0.00008001461,0.00413167,0.00006126536,0.004066142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328571,"threshold_uncertainty_score":0.00444448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004500014377862801,"score_gpt":0.1869700163976456,"score_spread":0.1824700020197828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}