{"id":"W2135313485","doi":"10.1161/circgenetics.111.961342","title":"A Genetic Risk Score Is Associated With Incident Cardiovascular Disease and Coronary Artery Calcium","year":2012,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Single-nucleotide polymorphism; Hazard ratio; Medicine; Internal medicine; Odds ratio; SNP; Coronary artery disease; Myocardial infarction; Framingham Risk Score; Genome-wide association study; Disease; Genetics; Confidence interval; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00114728,0.0004067924,0.0006001158,0.00009774778,0.0003076644,0.00004325076,0.0001843259,0.0003372964,0.00001639751],"category_scores_gemma":[0.0003140847,0.0004006462,0.000861607,0.0002219985,0.0001976067,0.00001394755,0.0001742855,0.0001883678,0.00001687958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008625516,"about_ca_system_score_gemma":0.0001332178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004147351,"about_ca_topic_score_gemma":0.00000949178,"domain_scores_codex":[0.9968228,0.0006333782,0.0004670157,0.0007622002,0.0006168922,0.0006976548],"domain_scores_gemma":[0.9976355,0.00004229338,0.0002078582,0.00134739,0.0002784419,0.0004884886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002715692,0.00007100441,0.9447031,0.00002002449,0.006862867,0.00001596495,0.0001410926,0.04050993,0.0004167671,0.00000384143,0.0002497863,0.006978447],"study_design_scores_gemma":[0.001110192,0.00008916261,0.9866439,0.00001954997,0.002494336,0.0001431781,0.00006568964,0.001765553,0.0001574284,0.000065723,0.006913594,0.0005317542],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8893217,0.06867509,0.04095018,0.00002851254,0.0002224994,0.0006043888,0.00008925606,0.00003295097,0.00007537753],"genre_scores_gemma":[0.9940926,0.003155534,0.001378177,0.0002471938,0.0006069264,0.0001040408,0.0002830823,0.0000849572,0.00004747644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1047709,"threshold_uncertainty_score":0.9998446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108683150047352,"score_gpt":0.2298101973052525,"score_spread":0.208723365804779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}