{"id":"W2135327444","doi":"10.1016/j.bbadis.2007.05.001","title":"The prion protein family: Diversity, rivalry, and dysfunction","year":2007,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto","funders":"","keywords":"PRNP; Biology; Gene isoform; Prion protein; Function (biology); Scrapie; Protein family; Gene; Genetics; Cell biology; Disease; Allele; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004481225,0.0007240813,0.000823291,0.0001652177,0.0004716687,0.0001264706,0.0008491874,0.0003990564,0.000005173006],"category_scores_gemma":[0.0002118324,0.000574558,0.001092844,0.0003242113,0.0003850515,0.00001546592,0.001812456,0.0003052151,0.000008713136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004818957,"about_ca_system_score_gemma":0.0004406792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002497441,"about_ca_topic_score_gemma":0.000002132991,"domain_scores_codex":[0.9968034,0.0004409501,0.0006530912,0.001013836,0.0005674574,0.0005212571],"domain_scores_gemma":[0.9973838,0.00005833031,0.000693238,0.001231957,0.0001535608,0.0004791257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007305043,0.0004330223,0.000003154021,0.006619577,0.001176912,0.00002955225,0.00002084703,0.000001021663,0.2209248,0.0003871817,0.0008223276,0.7688512],"study_design_scores_gemma":[0.001618285,0.0009198292,0.0006163031,0.006721109,0.005044383,0.00001071851,0.00006274151,0.00001536662,0.1733025,0.000657323,0.8084522,0.002579186],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1491494,0.8484111,0.0001375502,0.0001765427,0.0001208991,0.001592882,0.0003110223,0.00003169826,0.00006897946],"genre_scores_gemma":[0.07253283,0.9260017,0.0001756374,0.0001682065,0.0001934163,0.0001297313,0.0006298939,0.0001043118,0.00006427987],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8076299,"threshold_uncertainty_score":0.9996706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666201369358293,"score_gpt":0.3005536349917292,"score_spread":0.2738916212981462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}