{"id":"W2135327444","doi":"10.1016/j.bbadis.2007.05.001","title":"The prion protein family: Diversity, rivalry, and dysfunction","year":2007,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Toronto","funders":"","keywords":"PRNP; Biology; Gene isoform; Prion protein; Function (biology); Scrapie; Protein family; Gene; Genetics; Cell biology; Disease; Allele; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006998369,0.0009730212,0.001819731,0.001626962,0.0003502036,0.001307526,0.001245218,0.001344427,0.001469519],"category_scores_gemma":[0.0006816741,0.0002616739,0.0002529831,0.002151093,0.0009683351,0.001620922,0.0006916414,0.001667997,0.001368208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006778519,"about_ca_system_score_gemma":0.001002975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008193873,"about_ca_topic_score_gemma":0.001111243,"domain_scores_codex":[0.9998084,0.00002511891,0.00002339215,0.00003933415,0.00008725572,0.00001665159],"domain_scores_gemma":[0.9996578,0.0001373047,0.00005534255,0.00001418966,0.00008351934,0.00005196819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009986271,0.00005286676,0.0003537381,0.005267261,0.00005828085,0.0005926931,0.00009062485,0.0003369833,0.004955614,0.004542795,0.02371642,0.9599328],"study_design_scores_gemma":[0.000031856,0.00009893912,0.001495796,0.001185031,0.0000891416,0.006120764,0.0001238813,0.0001611716,0.001286236,0.005336701,0.9840409,0.00002970187],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002005806,0.9987691,0.0001714532,0.000206541,0.0001174932,0.00000202244,0.000008192907,0.000005504656,0.0005190655],"genre_scores_gemma":[0.001119082,0.9980646,0.0001991965,0.0001123368,0.0001602218,0.000004008341,0.00002174668,7.152837e-7,0.0003180999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001819731,"threshold_uncertainty_score":0.004918218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666201369358293,"score_gpt":0.3005536349917292,"score_spread":0.2738916212981462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}