{"id":"W2135336914","doi":"10.1371/journal.pone.0003583","title":"Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Hamilton General Hospital; McMaster University; McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Center for Research Resources; Broad Institute; National Heart, Lung, and Blood Institute; University of Pennsylvania; Massachusetts Institute of Technology","keywords":"International HapMap Project; Genome-wide association study; Biology; Single-nucleotide polymorphism; Genetics; Genetic association; Expression quantitative trait loci; Computational biology; Quantitative trait locus; SNP; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005290392,0.0006159166,0.001057962,0.0008993491,0.0006279701,0.001626568,0.00257398,0.001376819,0.007065823],"category_scores_gemma":[0.003155189,0.0007670657,0.0006226506,0.000975127,0.0006982979,0.000675564,0.001814342,0.001125386,0.003542096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005509833,"about_ca_system_score_gemma":0.002225801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082838,"about_ca_topic_score_gemma":0.001380102,"domain_scores_codex":[0.9962949,0.001198835,0.0001757253,0.0008678152,0.001083132,0.0003795105],"domain_scores_gemma":[0.9979752,0.0004907534,0.0002294361,0.0003935046,0.0004730371,0.0004380552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003803097,0.001353464,0.0369879,0.0009611583,0.0003868399,0.001049992,0.0007118428,0.03745615,0.5667216,0.03164518,0.01948196,0.2994409],"study_design_scores_gemma":[0.002797257,0.01443618,0.06197296,0.0004151198,0.0008773052,0.003381465,0.0005348045,0.2955374,0.3178047,0.02861309,0.2728588,0.0007708077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02871942,0.0002312382,0.9538289,0.0005461677,0.0003140081,0.003964055,0.002111091,0.00426662,0.006018617],"genre_scores_gemma":[0.1128492,0.0002256417,0.8697789,0.001270526,0.0001314933,0.00964824,0.001901781,0.0003063455,0.003887857],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007065823,"threshold_uncertainty_score":0.0279786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05506668951506644,"score_gpt":0.2822921642948574,"score_spread":0.227225474779791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}