{"id":"W2135341518","doi":"10.2337/diabetes.55.03.06.db05-1418","title":"Haplotype Structures and Large-Scale Association Testing of the 5′ AMP-Activated Protein Kinase Genes <i>PRKAA2</i>, <i>PRKAB1</i>, and <i>PRKAB2</i> With Type 2 Diabetes","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Novo Nordisk; Novo Nordisk Fonden; Academy of Finland; Boston Area Diabetes Endocrinology Research Center; Diabetestutkimussäätiö; Rockefeller Brothers Fund; National Institutes of Health; Richard and Susan Smith Family Foundation","keywords":"Type 2 diabetes; AMPK; Gene; Haplotype; Biology; Genetic association; Genetics; Protein kinase A; Phenotype; Metformin; Single-nucleotide polymorphism; Candidate gene; Diabetes mellitus; Endocrinology; Kinase; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001691546,0.0002553543,0.0004306879,0.001046506,0.0005753096,0.0004180908,0.0004966441,0.0003976899,0.001555858],"category_scores_gemma":[0.006005614,0.0002340503,0.0005476184,0.001208753,0.0005481594,0.0002545328,0.0004689638,0.0005742515,0.0002327252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181657,"about_ca_system_score_gemma":0.0002789182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002423383,"about_ca_topic_score_gemma":0.003007445,"domain_scores_codex":[0.9977818,0.001126234,0.000135944,0.0006622321,0.0001544328,0.0001394391],"domain_scores_gemma":[0.9929786,0.004103023,0.001427497,0.0008280654,0.0002371157,0.000425682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001425668,0.0001108909,0.9676374,0.00002920427,0.0008593995,0.0007739755,0.0002960489,0.004788046,0.01370607,0.0005722701,0.0003122272,0.009488842],"study_design_scores_gemma":[0.0001013327,0.0002504424,0.9843094,0.00001132182,0.0003940535,0.0008339233,0.0001242867,0.01088816,0.001608304,0.0009509319,0.0005022676,0.00002560967],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982098,0.00007383853,0.001322296,0.00001821267,0.00000377014,0.00000737976,0.0001667,0.000009193302,0.000188784],"genre_scores_gemma":[0.9990698,0.00001950866,0.0005877825,0.00001104221,0.000005504035,0.000009431737,0.0002431712,0.000004119423,0.00004976848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002423383,"threshold_uncertainty_score":0.008945882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005341614405010441,"score_gpt":0.1948561042607824,"score_spread":0.1895144898557719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}