{"id":"W2135342180","doi":"10.1128/mcb.22.12.4167-4180.2002","title":"Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of General Medical Sciences; National Institutes of Health; Jane Coffin Childs Memorial Fund for Medical Research","keywords":"Biology; Chromatin; Histone H4; Histone; Saccharomyces cerevisiae; Histone deacetylase; ChIP-on-chip; Chromatin immunoprecipitation; Acetylation; Genetics; Histone H3; Cell biology; DNA; Histone H2A; Yeast; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705986,0.0004639328,0.0002306841,0.0002078787,0.0002040295,0.0004914049,0.0003025754,0.0002455317,0.0009149087],"category_scores_gemma":[0.000185546,0.0004359945,0.0003781089,0.0001233483,0.0002366675,0.0002840396,0.0003888822,0.0004162843,0.0007453798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000552371,"about_ca_system_score_gemma":0.000285604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002167626,"about_ca_topic_score_gemma":0.002673605,"domain_scores_codex":[0.9998636,0.00001370443,0.00001333793,0.00003680141,0.00004568711,0.00002690295],"domain_scores_gemma":[0.9998642,0.00001898903,0.00003062881,0.00001715843,0.00003121019,0.00003778999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009511007,0.00001177978,0.0004167425,0.00004584242,0.000007189976,0.0001367681,0.00002148029,0.0001692202,0.9977847,0.0002527935,0.00003823843,0.001020173],"study_design_scores_gemma":[0.00002485067,0.00008024801,0.01018281,0.000006708807,0.00001780242,0.0002355914,0.00003843588,0.002034186,0.9851153,0.0001496062,0.002105316,0.000009046698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845003,0.002560831,0.0107346,0.00007038784,0.00003032357,0.0000257015,0.0003131314,0.0003545104,0.001410379],"genre_scores_gemma":[0.9885297,0.001066485,0.006569885,0.00005532661,0.000009327394,0.0000374794,0.0008964458,0.00005870847,0.002776633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002167626,"threshold_uncertainty_score":0.004310071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997938815073859,"score_gpt":0.2675840981445521,"score_spread":0.2476047099938136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}