{"id":"W2135363140","doi":"10.1128/iai.01037-12","title":"Cryptococcus neoformans Requires the ESCRT Protein Vps23 for Iron Acquisition from Heme, for Capsule Formation, and for Virulence","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Burroughs Wellcome Fund","keywords":"Cryptococcus neoformans; Biology; Virulence; ESCRT; Heme; Microbiology; Capsule; Virology; Endosome; Cell biology; Enzyme; Biochemistry; Gene; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005664353,0.000336572,0.0001819562,0.0001534141,0.0001808456,0.0002661336,0.000131425,0.000246327,0.0006804603],"category_scores_gemma":[0.0001257607,0.00007837539,0.0001453451,0.0001630772,0.0001651755,0.0001240825,0.0002314122,0.0002087634,0.0002567887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003527376,"about_ca_system_score_gemma":0.0002760771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002730993,"about_ca_topic_score_gemma":0.002640394,"domain_scores_codex":[0.9999193,0.000007365074,0.000005491238,0.00001270813,0.00003110927,0.00002397616],"domain_scores_gemma":[0.9999249,0.000008210035,0.00002946071,0.000009325528,0.0000106286,0.00001751464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004503121,0.0000128334,0.00112162,0.00001751491,0.000004046305,0.0002540206,0.000009949663,0.00008134727,0.9965833,0.00007528719,0.00002992767,0.001765143],"study_design_scores_gemma":[0.00000957953,0.0001583614,0.05494167,0.00001766085,0.00001737969,0.003398769,0.0001417241,0.001307486,0.9360154,0.0001418507,0.003841917,0.000008235932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976725,0.0004460046,0.0007820289,0.00005366396,0.000004895635,0.000006381197,0.000139818,0.00002677415,0.0008679748],"genre_scores_gemma":[0.9980452,0.0001795952,0.0006035913,0.00002237242,0.000001184443,0.000005045554,0.00018302,0.000006356547,0.0009536609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002730993,"threshold_uncertainty_score":0.005430162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03930159174265296,"score_gpt":0.3125079693532563,"score_spread":0.2732063776106033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}