{"id":"W2135371035","doi":"10.1093/jac/45.4.433","title":"Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa","year":2000,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Foundation","keywords":"Efflux; Pseudomonas aeruginosa; Bacterial outer membrane; Microbiology; Antibiotics; Multiple drug resistance; Membrane permeability; Biology; Antibiotic resistance; Mutant; Chemistry; Membrane; Bacteria; Biochemistry; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002512373,0.000237455,0.0003561645,0.0001856243,0.0002323365,0.0005211189,0.0001600123,0.0003934107,0.0003948303],"category_scores_gemma":[0.0003719906,0.0001620256,0.0001294449,0.0001037625,0.0003279086,0.0004958563,0.0002890054,0.0005077437,0.0001883814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032621,"about_ca_system_score_gemma":0.0002450723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002973588,"about_ca_topic_score_gemma":0.0004311162,"domain_scores_codex":[0.9998068,0.00007094249,0.000009897764,0.00001892163,0.0000515083,0.00004196262],"domain_scores_gemma":[0.9997973,0.00006393126,0.00003938829,0.00001883723,0.00002793158,0.00005279374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006403418,0.00001648225,0.0003138765,0.00001846409,0.000002835253,0.0001008514,0.00001318277,0.00008891512,0.9981317,0.0001599978,0.00001401723,0.001075589],"study_design_scores_gemma":[0.00002604274,0.0003933569,0.01977392,0.00001679202,0.00003398532,0.001108972,0.0001398598,0.004016601,0.9721172,0.0005616299,0.001789442,0.00002221338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959716,0.001919014,0.001386522,0.0001883161,0.000006407649,0.000005517432,0.00001844269,0.00001739401,0.0004867982],"genre_scores_gemma":[0.9987676,0.0004628527,0.0004326587,0.00002761529,0.000003007572,0.000005635358,0.00002179262,0.000005385364,0.0002734941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005211189,"threshold_uncertainty_score":0.002200365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004984750785968608,"score_gpt":0.2352465817786024,"score_spread":0.2302618309926338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}