{"id":"W2135374303","doi":"10.1128/jvi.77.2.1427-1440.2003","title":"The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Molecular biology; Cell biology; Endosome; Major histocompatibility complex; MHC class I; Downregulation and upregulation; Kaposi's sarcoma-associated herpesvirus; Gene; Biochemistry; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464774,0.0003023409,0.000222511,0.0001189015,0.0002000373,0.0002477369,0.0002221637,0.0003157345,0.0007640848],"category_scores_gemma":[0.0001225842,0.0001595082,0.0003062562,0.00007352028,0.0003539316,0.0001420194,0.0002331612,0.00036217,0.0005180936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005111658,"about_ca_system_score_gemma":0.0001157119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002688232,"about_ca_topic_score_gemma":0.0002647818,"domain_scores_codex":[0.9998907,0.00002083171,0.00001090791,0.00002783144,0.00002689175,0.00002272268],"domain_scores_gemma":[0.9999307,0.000008527981,0.00002705198,0.00001272825,0.000004888062,0.00001603243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008042493,0.00001379357,0.0003146422,0.00002765636,0.000004076365,0.0001099859,0.000006438742,0.00003997828,0.9984241,0.0001127074,0.00003956289,0.0008267226],"study_design_scores_gemma":[0.00003039127,0.0002837885,0.004524278,0.00000529202,0.00001520755,0.001459451,0.00001425136,0.0008936177,0.9886596,0.00004987604,0.004059192,0.000005024519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995654,0.001344663,0.001841057,0.0000850829,0.00002358315,0.0000189,0.0001398053,0.00005816976,0.0008347111],"genre_scores_gemma":[0.9954283,0.0004116809,0.001965372,0.00004632403,0.00001405066,0.00001951784,0.0004626715,0.00001352697,0.001638672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007640848,"threshold_uncertainty_score":0.003708839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02782863311195295,"score_gpt":0.2770630130909066,"score_spread":0.2492343799789537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}