{"id":"W2135374303","doi":"10.1128/jvi.77.2.1427-1440.2003","title":"The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Molecular biology; Cell biology; Endosome; Major histocompatibility complex; MHC class I; Downregulation and upregulation; Kaposi's sarcoma-associated herpesvirus; Gene; Biochemistry; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007241427,0.0001108012,0.0001951158,0.0000790081,0.00009273674,0.00001637567,0.0003098646,0.0001380054,0.0000824478],"category_scores_gemma":[0.00009705636,0.00006706125,0.0001050522,0.00008986083,0.0004113163,0.00001009633,0.00008318566,0.0001985392,0.000001006192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001161157,"about_ca_system_score_gemma":0.00004471104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000878545,"about_ca_topic_score_gemma":0.00002907299,"domain_scores_codex":[0.9986585,0.0003982704,0.000410573,0.0001277175,0.0002252043,0.0001797123],"domain_scores_gemma":[0.9989356,0.00004968835,0.0005740818,0.0002295246,0.0001607415,0.00005038747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001843756,0.00006147511,0.0008883771,0.00001277101,0.0001334592,0.000004875812,0.0002514452,0.00001075373,0.9767178,0.00004450245,0.0002312669,0.01979946],"study_design_scores_gemma":[0.0008847553,0.004612503,0.001385245,0.00002314112,0.00002346451,0.0002029709,0.0002008682,0.00005945214,0.9905818,0.0006283001,0.001335231,0.00006223691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932117,0.004877672,0.0002120642,0.001370967,0.000078078,0.0001737849,0.000006362,0.000001331344,0.00006808351],"genre_scores_gemma":[0.9975525,0.001879638,0.0001211901,0.0001929103,0.0001685548,0.000006920226,0.000001316507,0.0000134789,0.00006353058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01973722,"threshold_uncertainty_score":0.2734678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02782863311195295,"score_gpt":0.2770630130909066,"score_spread":0.2492343799789537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}