{"id":"W2135432827","doi":"10.1158/1078-0432.ccr-07-4899","title":"Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Research UK","keywords":"Ovarian cancer; Antigen; Cancer research; Tumor antigen; Epitope; CD40; Hypochlorous acid; Ovarian tumor; Antigen-presenting cell; Medicine; Cytotoxic T cell; Immunology; Immunotherapy; Immune system; T cell; Biology; Cancer; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007438551,0.0002177528,0.0001521235,0.00009881868,0.00008749458,0.0001538602,0.00006037534,0.0001971775,0.001414848],"category_scores_gemma":[0.0000834599,0.00007177144,0.00019916,0.00006333136,0.00009641744,0.00008453779,0.000153359,0.0002350533,0.0002810736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301479,"about_ca_system_score_gemma":0.00008659604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003420295,"about_ca_topic_score_gemma":0.0005899579,"domain_scores_codex":[0.9999053,0.00001833275,0.000004660021,0.00001342376,0.00001763862,0.0000406141],"domain_scores_gemma":[0.9999472,0.00001348682,0.000009791685,0.000008385437,0.000008737406,0.00001244883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336944,0.00002178444,0.000405298,0.00001778834,0.000002893756,0.00003450458,0.00001548224,0.00002600866,0.9986185,0.000008438174,0.00001694357,0.0006987464],"study_design_scores_gemma":[0.00008021136,0.002485335,0.02558268,0.00001107295,0.00003729819,0.0008175682,0.0001110475,0.0007085723,0.9671944,0.00004169554,0.002925718,0.000004460896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987563,0.0003306762,0.0002423135,0.00001686477,0.000006857169,0.00001287619,0.00002751823,0.000009236688,0.0005973035],"genre_scores_gemma":[0.9989429,0.0001689736,0.0002209635,0.00003873988,0.000008688427,0.000009713803,0.00009053418,0.00000376475,0.0005157068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414848,"threshold_uncertainty_score":0.004733086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074929394584901,"score_gpt":0.3800637311833616,"score_spread":0.2725707917248715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}