{"id":"W2135432827","doi":"10.1158/1078-0432.ccr-07-4899","title":"Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Research UK","keywords":"Ovarian cancer; Antigen; Cancer research; Tumor antigen; Epitope; CD40; Hypochlorous acid; Ovarian tumor; Antigen-presenting cell; Medicine; Cytotoxic T cell; Immunology; Immunotherapy; Immune system; T cell; Biology; Cancer; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001827876,0.0003203644,0.0008894876,0.0001608855,0.0005131795,0.00002435545,0.0005585627,0.0004514438,0.001316838],"category_scores_gemma":[0.0001990602,0.0002686623,0.0001838327,0.0003294289,0.001918674,0.0002002417,0.0003848314,0.001211683,0.0002041388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341666,"about_ca_system_score_gemma":0.0005621737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856096,"about_ca_topic_score_gemma":0.00009299432,"domain_scores_codex":[0.9957208,0.001432621,0.000878063,0.0008961658,0.0002428149,0.0008295571],"domain_scores_gemma":[0.9973197,0.001284542,0.0003392971,0.0004862716,0.0004556708,0.0001145014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001876313,0.0003183379,0.001487811,0.00006679835,0.000264229,0.0000279082,0.0001950428,0.000002605589,0.9766192,0.00002104823,0.004069357,0.01505138],"study_design_scores_gemma":[0.002465425,0.000836856,0.009172602,0.0001034623,0.0000546703,0.00001931163,0.00006628444,0.000003849184,0.9820948,0.000239597,0.004652138,0.0002910443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831876,0.01374084,0.00008785351,0.000388912,0.001160953,0.0007113175,0.0005106456,0.00005437269,0.0001575358],"genre_scores_gemma":[0.9759755,0.02139079,0.0002399695,0.0003226694,0.0001558803,0.0001627896,0.00008457495,0.00004235529,0.001625519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01476034,"threshold_uncertainty_score":0.9999766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074929394584901,"score_gpt":0.3800637311833616,"score_spread":0.2725707917248715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}