{"id":"W2135455134","doi":"10.1093/hmg/ddr118","title":"The MYH9/APOL1 region and chronic kidney disease in European-Americans","year":2011,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University Health Network","funders":"National Center for Research Resources; National Human Genome Research Institute; U.S. Public Health Service; National Institutes of Health; National Heart, Lung, and Blood Institute; School of Medicine, Boston University","keywords":"Kidney disease; Single-nucleotide polymorphism; Odds ratio; Biology; Framingham Heart Study; Internal medicine; SNP; Minor allele frequency; Renal function; Confidence interval; Diabetes mellitus; Allele frequency; Type 2 diabetes; Allele; Genetics; Genotype; Framingham Risk Score; Disease; Endocrinology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000127559,0.0004001388,0.0007478776,0.0001378724,0.0001351911,0.0000546799,0.0002277037,0.00008464237,0.00001800599],"category_scores_gemma":[0.0001020608,0.0002702542,0.0003723999,0.0002023183,0.0003304159,0.00001122606,0.0001768624,0.0003388091,0.00004342395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008481553,"about_ca_system_score_gemma":0.0004272024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001530064,"about_ca_topic_score_gemma":0.000004972568,"domain_scores_codex":[0.9981488,0.0003431009,0.0004818693,0.0004586539,0.0002046021,0.000362952],"domain_scores_gemma":[0.9983091,0.00002772597,0.000213805,0.0008373426,0.00004245629,0.0005695772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002283085,0.000107955,0.0001496412,0.01419618,0.0001817596,0.00219653,0.00007540954,0.000001085315,0.00001401664,0.0009395129,0.001667246,0.9804478],"study_design_scores_gemma":[0.0003032113,0.0001940489,0.002198875,0.008603156,0.001358275,0.00004701098,0.000007398004,0.000005790544,8.181965e-7,0.0001822395,0.9868007,0.0002984765],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002868973,0.9967193,0.00004773473,0.00005204646,0.00006583141,0.000748945,0.00002217648,0.00002656318,0.002030479],"genre_scores_gemma":[0.0009661075,0.9977536,0.00003301177,0.0002334662,0.0001867905,0.00005144541,0.0001372898,0.0001176427,0.0005206017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9851335,"threshold_uncertainty_score":0.999975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368986009804028,"score_gpt":0.3179883804181551,"score_spread":0.2742985203201149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}