{"id":"W2135455134","doi":"10.1093/hmg/ddr118","title":"The MYH9/APOL1 region and chronic kidney disease in European-Americans","year":2011,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University Health Network","funders":"National Center for Research Resources; National Human Genome Research Institute; U.S. Public Health Service; National Institutes of Health; National Heart, Lung, and Blood Institute; School of Medicine, Boston University","keywords":"Kidney disease; Single-nucleotide polymorphism; Odds ratio; Biology; Framingham Heart Study; Internal medicine; SNP; Minor allele frequency; Renal function; Confidence interval; Diabetes mellitus; Allele frequency; Type 2 diabetes; Allele; Genetics; Genotype; Framingham Risk Score; Disease; Endocrinology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002229511,0.0004114849,0.0008839285,0.0007041405,0.0003873653,0.0006753136,0.0004085924,0.0007846626,0.001336616],"category_scores_gemma":[0.002671249,0.0004286877,0.00182187,0.001465934,0.000309978,0.0002963818,0.0004310707,0.0004179207,0.000109394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797742,"about_ca_system_score_gemma":0.0002051784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004024806,"about_ca_topic_score_gemma":0.004950712,"domain_scores_codex":[0.9990219,0.0004046242,0.0001076613,0.0003043988,0.00008540653,0.00007608539],"domain_scores_gemma":[0.9990367,0.000453725,0.0002562699,0.0001103616,0.00006281753,0.00008019357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005155597,0.0001028409,0.9686731,0.0003789189,0.01335086,0.0003246333,0.000121708,0.0003181049,0.002680772,0.00010453,0.0002894972,0.008499539],"study_design_scores_gemma":[0.0004008889,0.0002803667,0.9887189,0.00006773153,0.008516703,0.0003241019,0.00008997425,0.0004858839,0.0002935097,0.0001836658,0.0006259917,0.00001230423],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9851438,0.01365091,0.0002965961,0.0001542329,0.0000234849,0.00000988981,0.0002932654,0.000008994817,0.0004188036],"genre_scores_gemma":[0.9965457,0.00251701,0.000341514,0.0001357025,0.00004150592,0.00001852943,0.0002330881,0.000004075041,0.0001628196],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004024806,"threshold_uncertainty_score":0.01179093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368986009804028,"score_gpt":0.3179883804181551,"score_spread":0.2742985203201149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}