{"id":"W2135458863","doi":"10.1084/jem.191.8.1319","title":"A Novel B Lymphocyte–Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Medical Research Council; National Institutes of Health; National Institute of Dental and Craniofacial Research; Medical Research Council Canada","keywords":"Pleckstrin homology domain; Signal transducing adaptor protein; Molecular biology; Biology; B-cell receptor; LYN; Cell biology; breakpoint cluster region; Signal transduction; Phosphatidylinositol; B cell; Proto-oncogene tyrosine-protein kinase Src; Receptor; Antibody; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119345,0.0004077771,0.0002048375,0.0001896995,0.000163249,0.000324018,0.0001999902,0.0002823567,0.0009242974],"category_scores_gemma":[0.0001401059,0.00009919093,0.0001875789,0.00015024,0.0001485665,0.0002866441,0.0002915532,0.0003724883,0.0006636126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093814,"about_ca_system_score_gemma":0.000141545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001881414,"about_ca_topic_score_gemma":0.0001969246,"domain_scores_codex":[0.9999329,0.000008909091,0.00000465323,0.00001469355,0.00002166787,0.00001716124],"domain_scores_gemma":[0.9998928,0.00001313015,0.00003482479,0.000007765438,0.00001395034,0.00003745288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001061853,0.0000169706,0.0007884628,0.00003789526,0.000003742218,0.0002560955,0.00001752173,0.00005181802,0.9963927,0.000187572,0.00005636069,0.002084661],"study_design_scores_gemma":[0.00009616326,0.0007184107,0.03630486,0.00002618738,0.00005984184,0.006767577,0.0001267495,0.003914839,0.9247386,0.0004572976,0.0267661,0.00002346182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898282,0.004221812,0.004607928,0.00009910682,0.00002739139,0.00002415615,0.000224221,0.00006552385,0.0009016154],"genre_scores_gemma":[0.9882925,0.001651922,0.006287726,0.00006214112,0.00002537377,0.00003623425,0.001316355,0.00001408853,0.002313713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009242974,"threshold_uncertainty_score":0.003092051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281420166800018,"score_gpt":0.2375518599846945,"score_spread":0.2247376583166943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}