{"id":"W2135488334","doi":"10.1124/mol.114.097337","title":"Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Functional selectivity; Angiotensin II; MAPK/ERK pathway; Signal transduction; Receptor; Cell biology; Angiotensin II receptor type 1; Protein kinase C; Heterotrimeric G protein; G protein-coupled receptor; Gq alpha subunit; Chemistry; Biology; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659359,0.0001848931,0.0001512746,0.0001488955,0.0001388763,0.0003116608,0.0002250478,0.0001726893,0.002154403],"category_scores_gemma":[0.000307512,0.0001043966,0.0001862973,0.00009180311,0.0002414765,0.0002197634,0.0001208009,0.0005425145,0.000486207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377567,"about_ca_system_score_gemma":0.0001925996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006998329,"about_ca_topic_score_gemma":0.0005631435,"domain_scores_codex":[0.9999053,0.0000265432,0.000005806773,0.00001300656,0.00001679121,0.00003239701],"domain_scores_gemma":[0.9997471,0.000103407,0.00004940938,0.0000232319,0.00002707183,0.00004969727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001808465,0.0000269522,0.000328737,0.000008258609,0.000002107085,0.00007145674,0.00001308232,0.00007516119,0.9980268,0.0005190392,0.00001599871,0.000731418],"study_design_scores_gemma":[0.00002381309,0.0001673259,0.009016197,0.000003523606,0.00001404201,0.0005271012,0.00004594512,0.002107875,0.9868465,0.0002778827,0.0009621634,0.000007698356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950729,0.0002158066,0.003248795,0.00009751583,0.00001218767,0.00002001986,0.0001273911,0.00001663723,0.001188688],"genre_scores_gemma":[0.9973975,0.0001476211,0.00131982,0.00004257108,0.00001187671,0.00001018387,0.0002043061,0.0000121426,0.0008538847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154403,"threshold_uncertainty_score":0.007207215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788298755274053,"score_gpt":0.2624441196140655,"score_spread":0.244561132061325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}