{"id":"W2135488334","doi":"10.1124/mol.114.097337","title":"Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Functional selectivity; Angiotensin II; MAPK/ERK pathway; Signal transduction; Receptor; Cell biology; Angiotensin II receptor type 1; Protein kinase C; Heterotrimeric G protein; G protein-coupled receptor; Gq alpha subunit; Chemistry; Biology; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003921094,0.0002097524,0.0002848418,0.0001393425,0.00004527319,0.000007985568,0.0001595823,0.0002534017,0.0001290535],"category_scores_gemma":[0.00006148741,0.0002307401,0.0001119498,0.0002468358,0.00006850466,0.00001032043,0.0001632217,0.0001400308,0.00000769752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004854777,"about_ca_system_score_gemma":0.0001946419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000223897,"about_ca_topic_score_gemma":0.0000118119,"domain_scores_codex":[0.9984171,0.0002707801,0.0003429516,0.0004398846,0.0002016015,0.0003276492],"domain_scores_gemma":[0.9992602,0.000006896448,0.0001695135,0.0001895058,0.0002382379,0.0001355716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002821466,0.0001794842,0.001433257,0.00001061498,0.00005559824,0.00002804466,0.00005686201,0.0003257043,0.9964338,0.0000442068,0.0004044184,0.0007458593],"study_design_scores_gemma":[0.001445688,0.0004676559,0.0007323564,0.00001012103,0.00002881631,0.00001281585,0.00001605705,0.0006495485,0.9924659,0.00007804391,0.003867401,0.0002255662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848267,0.0002343105,0.0137682,0.0001621478,0.0006108696,0.0003034105,0.00001615003,0.00001445093,0.00006371821],"genre_scores_gemma":[0.9979908,0.00002936851,0.0008478233,0.0006010837,0.0001328337,0.00004213663,0.0002307212,0.00003685848,0.00008835972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01316407,"threshold_uncertainty_score":0.9409308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788298755274053,"score_gpt":0.2624441196140655,"score_spread":0.244561132061325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}