{"id":"W2135497148","doi":"10.1158/1538-7445.am2013-lb-289","title":"Abstract LB-289: A phase I dose escalation study of TKM-080301, a RNAi therapeutic directed against PLK1, in patients with advanced solid tumors.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Medicine; PLK1; Pharmacokinetics; Chills; Adverse effect; Pharmacodynamics; Kinase; Pharmacology; Neutropenia; Cmax; Nausea; Cell cycle; Internal medicine; Toxicity; Oncology; Cancer research; Cancer; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142061,0.0001555023,0.0002259138,0.0001378273,0.00007130365,0.00003950231,0.0002227215,0.00007914454,0.0000767504],"category_scores_gemma":[0.00009613572,0.00013449,0.00003355069,0.0003305686,0.00008513001,0.00001259733,0.0001044738,0.0002096357,0.00000798518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001061407,"about_ca_system_score_gemma":0.0002766814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00087146,"about_ca_topic_score_gemma":0.0007771806,"domain_scores_codex":[0.9984329,0.00008203519,0.0003097883,0.0004023182,0.0003712907,0.0004016504],"domain_scores_gemma":[0.9988024,0.00005370374,0.0001084495,0.0004053173,0.0005174368,0.0001126503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003073933,0.004880928,0.154731,0.00009489808,0.0001711405,0.000009283582,0.000883649,0.002317239,0.7159687,0.000007778676,0.0006998483,0.1171616],"study_design_scores_gemma":[0.01396443,0.004679753,0.9083841,0.0001540957,0.00001591439,2.99893e-7,0.0006032587,0.0002644963,0.07053393,0.00005873085,0.0009558094,0.0003851256],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974486,0.0007068291,0.000008035873,0.00004410077,0.00005551002,0.001442165,0.00005884992,0.000008613634,0.0002272771],"genre_scores_gemma":[0.9987105,0.0004530775,0.00003420064,0.00005140984,0.00007145601,0.000482785,0.0001198791,0.0000353936,0.00004126666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7536531,"threshold_uncertainty_score":0.5484341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02498979643351203,"score_gpt":0.3614604390467197,"score_spread":0.3364706426132076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}