{"id":"W2135510881","doi":"10.1124/pr.114.009639","title":"Cytokines as Therapeutic Targets in Rheumatoid Arthritis and Other Inflammatory Diseases","year":2015,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":308,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; McGill University Health Centre","funders":"","keywords":"Medicine; Rheumatoid arthritis; Immunology; Tumor necrosis factor alpha; Arthritis; Proinflammatory cytokine; Clinical trial; Inflammatory arthritis; Immune system; Inflammation; Bioinformatics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001246008,0.000743445,0.004259152,0.0003024714,0.00008690426,0.00007753057,0.0002992092,0.0003083781,0.002294172],"category_scores_gemma":[0.0006575025,0.0004588268,0.0006060266,0.0003963691,0.0003814346,0.00013316,0.0001986029,0.0009042189,0.001021242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475996,"about_ca_system_score_gemma":0.0004658419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001295324,"about_ca_topic_score_gemma":0.000009621608,"domain_scores_codex":[0.995399,0.001254794,0.001401713,0.0007322229,0.000492513,0.0007197574],"domain_scores_gemma":[0.9980176,0.0003621442,0.0003808765,0.0003471745,0.00008433321,0.0008078816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000760702,0.0002485038,0.0001848397,0.004951231,0.0001786463,0.000340809,0.00004788881,2.198105e-8,0.00000497144,0.0002219201,0.004416292,0.9893288],"study_design_scores_gemma":[0.001608775,0.0002714187,0.00003159414,0.02501799,0.00008512216,0.0004668076,0.00001022657,0.000002778801,0.000001485301,0.0005338712,0.9715375,0.0004323876],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009169822,0.9941574,0.000002348345,0.0001114049,0.0001692833,0.004139745,0.00006078219,0.0001005341,0.001166819],"genre_scores_gemma":[0.00006634416,0.9967264,0.00005263814,0.0009183757,0.0001920833,0.001730685,0.00006614165,0.00008345755,0.0001639002],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9888964,"threshold_uncertainty_score":0.9997863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010666040773339,"score_gpt":0.4143433618117486,"score_spread":0.3132767577344148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}