{"id":"W2135514623","doi":"10.1210/endo.142.2.7937","title":"Requirement of Ras-Dependent Pathways for Activation of the Transforming Growth Factor β3 Promoter by Estradiol**This work was supported by the Canadian Institutes of Health Research and the National Cancer Institute of Canada through the Canadian Breast Cancer Research Initiative program.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Protein kinase C; Biology; Estrogen receptor; Estrogen receptor alpha; Promoter; Cancer research; Kinase; Signal transduction; Internal medicine; Endocrinology; Cell biology; Chemistry; Cancer; Biochemistry; Genetics; Gene expression; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149999,0.0002785526,0.0001321982,0.0002295251,0.000191034,0.0003087761,0.0001583307,0.0001463305,0.001613777],"category_scores_gemma":[0.000124576,0.0001458007,0.0002313778,0.0001000278,0.0001554742,0.0001381084,0.0001930123,0.0003328044,0.0007440669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003672736,"about_ca_system_score_gemma":0.0005276522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002109191,"about_ca_topic_score_gemma":0.004228181,"domain_scores_codex":[0.9998937,0.00001518551,0.00001115691,0.00001558975,0.00004055677,0.00002381619],"domain_scores_gemma":[0.9998249,0.00003652423,0.00003939521,0.00002891523,0.00003309888,0.00003709728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000093295,0.00001358713,0.0001476607,0.00001641209,0.000002102918,0.00003817997,0.00001195127,0.00001526276,0.9985526,0.000125998,0.00001579692,0.0009670132],"study_design_scores_gemma":[0.00002030315,0.0001455402,0.01051521,0.00001439302,0.0000141713,0.0006242581,0.00004968903,0.001101175,0.9790349,0.0001307715,0.008344647,0.000004879089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882244,0.002353398,0.004272314,0.0001843598,0.00003896349,0.00005223128,0.0005593638,0.0001227957,0.00419212],"genre_scores_gemma":[0.9854404,0.001496506,0.004402883,0.00004849311,0.00001229741,0.00005713907,0.001490672,0.00002900985,0.007022537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109191,"threshold_uncertainty_score":0.005398571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09027767914381625,"score_gpt":0.3569723865431618,"score_spread":0.2666947073993456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}