{"id":"W2135523574","doi":"10.1126/science.1227670","title":"Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":740,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Somatic evolution in cancer; clone (Java method); Lineage (genetic); Cancer research; Colorectal cancer; Transplantation; Dominance (genetics); Repopulation; Chemotherapy; Genetics; Cancer; Stem cell; Gene; Internal medicine; Medicine; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007157639,0.00007049134,0.00006107142,0.00005337482,0.00007793619,0.0000278882,0.0001743751,0.0000552793,0.00001267897],"category_scores_gemma":[0.0003304272,0.0000723617,0.00001581029,0.0003246903,0.0001711684,0.00001565733,0.00007208569,0.0000502693,0.000003047141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001546102,"about_ca_system_score_gemma":0.0003862542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001759798,"about_ca_topic_score_gemma":0.0001581982,"domain_scores_codex":[0.9992079,0.00002080855,0.0001250433,0.0002172885,0.0001372329,0.0002916946],"domain_scores_gemma":[0.9996227,0.0000206897,0.00005290524,0.0001520153,0.00007004755,0.00008163469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003014305,0.00003277752,0.2428878,0.000002049068,0.000001682972,3.913005e-7,0.00007329578,0.002959684,0.7521759,0.0007040111,0.00003905685,0.0008218776],"study_design_scores_gemma":[0.0002940831,0.00009878365,0.8639578,0.000009698679,0.000002199296,0.00000859624,0.00002914294,0.002577459,0.1285052,0.0002205213,0.0041456,0.0001509741],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984019,0.0003337066,0.0004892779,0.0001353137,0.0002697985,0.00009434002,0.00001750098,0.000004477981,0.0002537118],"genre_scores_gemma":[0.9977134,0.00007631347,0.001663804,0.0003366446,0.0001049899,0.00002049923,0.00001001222,0.000006943571,0.0000673586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6236707,"threshold_uncertainty_score":0.2950825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005820318030524368,"score_gpt":0.2750315285554893,"score_spread":0.2692112105249649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}