{"id":"W2135523574","doi":"10.1126/science.1227670","title":"Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":740,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Somatic evolution in cancer; clone (Java method); Lineage (genetic); Cancer research; Colorectal cancer; Transplantation; Dominance (genetics); Repopulation; Chemotherapy; Genetics; Cancer; Stem cell; Gene; Internal medicine; Medicine; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485647,0.00008685357,0.0001306189,0.0002124228,0.00008973768,0.00029048,0.00009077469,0.0001576669,0.0003935962],"category_scores_gemma":[0.0004516857,0.0001016891,0.00006377888,0.0001360858,0.0001033307,0.0001258878,0.0001181449,0.0001788787,0.0001042306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265866,"about_ca_system_score_gemma":0.0001029128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006803831,"about_ca_topic_score_gemma":0.0009271689,"domain_scores_codex":[0.999898,0.00002616067,0.000007656929,0.00002205352,0.00002892338,0.00001725208],"domain_scores_gemma":[0.9997823,0.0000758649,0.00006425303,0.0000198643,0.00003130463,0.00002639694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001620017,0.00002743848,0.01647039,0.00001561644,0.000008518644,0.00005275591,0.00006073679,0.0006158777,0.9748368,0.00005495994,0.00003745692,0.007657537],"study_design_scores_gemma":[0.0000185611,0.0008153683,0.293231,0.00000794707,0.00005148472,0.0006709358,0.0001153992,0.008137424,0.695377,0.0001191193,0.00143999,0.0000157607],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992059,0.0002607107,0.0002860061,0.000008203529,7.424665e-7,0.000004101425,0.00002611505,0.0000113162,0.000196993],"genre_scores_gemma":[0.9995903,0.00009617981,0.0001351947,0.00000808659,7.697099e-7,0.000003836951,0.00003356148,0.000005030204,0.0001271426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006803831,"threshold_uncertainty_score":0.001928985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005820318030524368,"score_gpt":0.2750315285554893,"score_spread":0.2692112105249649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}