{"id":"W2135535764","doi":"10.1210/jc.2015-2134","title":"Activin A Increases Human Trophoblast Invasion by Inducing SNAIL-Mediated MMP2 Up-Regulation Through ALK4","year":2015,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; China Scholarship Council","keywords":"Biology; Gene knockdown; Trophoblast; Cytotrophoblast; MMP2; Cell biology; Endocrinology; Internal medicine; Cell culture; Downregulation and upregulation; Placenta; Fetus; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503257,0.0003231739,0.0001634217,0.0002291521,0.000117554,0.0002629799,0.00008511,0.0001405491,0.002694205],"category_scores_gemma":[0.0001201852,0.0001173778,0.0002899739,0.0001278338,0.0002064691,0.0001306438,0.0001768274,0.0004032833,0.0005835546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927131,"about_ca_system_score_gemma":0.0002227066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174337,"about_ca_topic_score_gemma":0.0005746435,"domain_scores_codex":[0.9998938,0.00002559087,0.00001473704,0.00001684462,0.00002483687,0.00002425491],"domain_scores_gemma":[0.9999255,0.00001940106,0.00002212655,0.000008440375,0.000006900471,0.00001759551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002039336,0.00004238175,0.0002189512,0.00004856646,0.00000497432,0.00004944771,0.0000120405,0.00003461619,0.9986295,0.00002508693,0.00004324875,0.0006873025],"study_design_scores_gemma":[0.00006469584,0.0006131124,0.006836358,0.000008924505,0.00002628728,0.0002883836,0.00004055093,0.0008228971,0.988862,0.00003385505,0.002399769,0.000003164044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936475,0.001655683,0.001679412,0.0001300214,0.00002796682,0.00004685679,0.0004844341,0.0000850201,0.002243036],"genre_scores_gemma":[0.9924982,0.001300465,0.002120931,0.00005223278,0.00001221422,0.00006260192,0.0007565361,0.00001699049,0.00317981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694205,"threshold_uncertainty_score":0.009013057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07058130097745778,"score_gpt":0.3711280526186357,"score_spread":0.3005467516411779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}