{"id":"W2135584158","doi":"10.1093/humrep/dem002","title":"Exposure of male rats to cyclophosphamide alters the chromatin structure and basic proteome in spermatozoa","year":2007,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Lawrence Livermore National Laboratory; McGill University","keywords":"Protamine; Sperm; Chromatin; Spermiogenesis; Biology; Acridine orange; Andrology; Spermatid; Histone; Chromomycin A3; Molecular biology; Genetics; DNA; Biochemistry; Medicine; Heterochromatin; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009540855,0.0006734745,0.0004515759,0.0006974785,0.0002178331,0.00023927,0.0002410084,0.0003787915,0.002715031],"category_scores_gemma":[0.0001173864,0.000264645,0.0002952677,0.0002131388,0.0003732023,0.0002396953,0.0002118026,0.0006468919,0.0004044081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003556652,"about_ca_system_score_gemma":0.0002932204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001669719,"about_ca_topic_score_gemma":0.002063163,"domain_scores_codex":[0.9998735,0.00001087478,0.000006827298,0.00004288373,0.00002554628,0.00004039025],"domain_scores_gemma":[0.9998073,0.00001232989,0.00006362784,0.00002212704,0.00002546306,0.00006907408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001624088,0.0001965955,0.001321767,0.00003904252,0.0000208389,0.0000949954,0.00003845445,0.00004182902,0.9941858,0.00004469562,0.00006662442,0.002325222],"study_design_scores_gemma":[0.0001223616,0.00928701,0.05997344,0.00002124091,0.0001295037,0.0005929684,0.0002006175,0.0004121753,0.9266322,0.0001146293,0.002490378,0.00002339825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974323,0.0007778546,0.0005902631,0.00007576848,0.00003147098,0.00002433089,0.0004601206,0.00008523909,0.000522637],"genre_scores_gemma":[0.9912422,0.001341229,0.001101964,0.00009557596,0.00002650788,0.0001073636,0.001105573,0.00002662371,0.004953004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002715031,"threshold_uncertainty_score":0.009082675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315424671415854,"score_gpt":0.2565214133110737,"score_spread":0.2433671665969152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}