{"id":"W2135611636","doi":"10.1210/jc.2007-2633","title":"Selective Loss of MEG3 Expression and Intergenic Differentially Methylated Region Hypermethylation in the MEG3/DLK1 Locus in Human Clinically Nonfunctioning Pituitary Adenomas","year":2008,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jarislowsky Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Massachusetts General Hospital; National Institutes of Health; Pfizer","keywords":"MEG3; Biology; DNA methylation; Pituitary neoplasm; Pituitary tumors; Pituitary adenoma; Methylation; Adenoma; Pituitary gland; Endocrinology; Gene expression; Gene; Long non-coding RNA; RNA; Genetics; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166218,0.0001951656,0.0001745345,0.0004577968,0.0001796788,0.0001600593,0.0001425389,0.0001719207,0.0007875293],"category_scores_gemma":[0.0002457373,0.0001312027,0.0001394135,0.0002493385,0.000294007,0.00006919273,0.0001657978,0.0001583421,0.0001670199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002626852,"about_ca_system_score_gemma":0.000154288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001651674,"about_ca_topic_score_gemma":0.002078744,"domain_scores_codex":[0.9998969,0.0000111654,0.00001107092,0.00003196014,0.00003052999,0.0000184163],"domain_scores_gemma":[0.9998406,0.00004362759,0.00004690785,0.00001914039,0.00001885914,0.00003077598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004189698,0.00001043795,0.02695269,0.00003474846,0.00001638772,0.0008139125,0.0001018194,0.00004597329,0.9701634,0.0000186967,0.00002678113,0.001396159],"study_design_scores_gemma":[0.00004287028,0.0005160035,0.6060863,0.000005116543,0.00008555292,0.01071432,0.0003050863,0.0005458549,0.3805166,0.00008774384,0.0010825,0.00001209062],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992626,0.000197811,0.0002496152,0.000009068411,0.000001642004,0.000004453625,0.0001070759,0.000008772055,0.0001589574],"genre_scores_gemma":[0.9994488,0.00006845594,0.0001641482,0.000007204002,0.000001618777,0.000004890573,0.0001843093,0.000003395506,0.0001170106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651674,"threshold_uncertainty_score":0.003284037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03647789990591279,"score_gpt":0.3285510932040372,"score_spread":0.2920731932981245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}