{"id":"W2135642491","doi":"10.1089/thy.2008.0091","title":"Thyroid-Stimulating Hormone and Free Thyroxine Levels in Persons with <i>HFE</i> C282Y Homozygosity, a Common Hemochromatosis Genotype: The HEIRS Study","year":2008,"lang":"en","type":"article","venue":"Thyroid","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institutes of Health; University of California, Irvine; Deutsches Krebsforschungszentrum; University of California, San Diego; National Human Genome Research Institute; University of Alabama; University of Alabama at Birmingham; University of Minnesota; London Health Sciences Centre; Wake Forest University; National Cancer Institute; Kaiser Permanente; McKnight Foundation","keywords":"Hemochromatosis; Internal medicine; Medicine; Endocrinology; Hereditary hemochromatosis; Thyroid-stimulating hormone; Newborn screening; Thyroid; Thyroid function; Free thyroxine; Genotype; Pediatrics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006887442,0.0003641512,0.000358573,0.0005531895,0.0004608255,0.0004517467,0.0002697205,0.0004581829,0.0007564909],"category_scores_gemma":[0.001202408,0.0002522136,0.0003442339,0.0004705142,0.0002835934,0.0002293667,0.0002700035,0.0004273743,0.0001360314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247578,"about_ca_system_score_gemma":0.0001694481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00684463,"about_ca_topic_score_gemma":0.007285966,"domain_scores_codex":[0.9996799,0.00009785545,0.00002862738,0.0000855582,0.00005995553,0.00004809143],"domain_scores_gemma":[0.9993036,0.0001211971,0.0002523159,0.00006354673,0.00007082243,0.0001884644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002559157,0.00003057163,0.9988411,0.000002881652,0.00003827691,0.00008376326,0.00006860535,0.00001490262,0.000301343,0.000006148492,0.00003475579,0.0003217248],"study_design_scores_gemma":[0.00001719702,0.0001192637,0.9992768,0.00000182576,0.00003279182,0.0002626519,0.00009211493,0.00007003499,0.00006850161,0.000008854016,0.00004828372,0.000001723987],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998038,0.00003102447,0.0000180907,0.000006747713,0.000001122579,0.000002513743,0.00005413747,7.09646e-7,0.00008184632],"genre_scores_gemma":[0.9998122,0.00001466093,0.00002054601,0.000008391906,0.000003533607,0.000002405665,0.00008406633,5.16766e-7,0.00005360393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00684463,"threshold_uncertainty_score":0.01360959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166974008741436,"score_gpt":0.2534942260410357,"score_spread":0.2318244859536213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}