{"id":"W2135642491","doi":"10.1089/thy.2008.0091","title":"Thyroid-Stimulating Hormone and Free Thyroxine Levels in Persons with <i>HFE</i> C282Y Homozygosity, a Common Hemochromatosis Genotype: The HEIRS Study","year":2008,"lang":"en","type":"article","venue":"Thyroid","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institutes of Health; University of California, Irvine; Deutsches Krebsforschungszentrum; University of California, San Diego; National Human Genome Research Institute; University of Alabama; University of Alabama at Birmingham; University of Minnesota; London Health Sciences Centre; Wake Forest University; National Cancer Institute; Kaiser Permanente; McKnight Foundation","keywords":"Hemochromatosis; Internal medicine; Medicine; Endocrinology; Hereditary hemochromatosis; Thyroid-stimulating hormone; Newborn screening; Thyroid; Thyroid function; Free thyroxine; Genotype; Pediatrics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004191279,0.0003845349,0.0006773539,0.0001641616,0.0005401915,0.00003864261,0.0003154308,0.0001057407,0.00002861633],"category_scores_gemma":[0.00009617698,0.0002499252,0.00007819013,0.0005827711,0.0003645857,0.0001669306,0.0002582242,0.0004925834,0.00001986259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004480594,"about_ca_system_score_gemma":0.0001073844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166767,"about_ca_topic_score_gemma":0.0008353426,"domain_scores_codex":[0.9978238,0.0001645545,0.000400525,0.0004916072,0.000575117,0.0005443664],"domain_scores_gemma":[0.9985285,0.0001836964,0.0001232482,0.000911347,0.00006305362,0.0001901123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00236416,0.003950097,0.8228235,0.0001899107,0.0003203714,0.001504108,0.06295545,0.0003682428,0.08594751,0.0003236725,0.01638682,0.002866185],"study_design_scores_gemma":[0.01479733,0.002993768,0.970326,0.00004799854,0.0003265852,0.000699531,0.008951492,0.0003583015,0.0007429839,0.0001296343,0.0001462082,0.0004801319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850224,0.008879567,0.00008123058,0.001582752,0.00003955601,0.001247626,0.00003383321,0.0001219933,0.002991102],"genre_scores_gemma":[0.9972633,0.0002790627,0.0008693978,0.0009046435,0.000115382,0.00005315392,0.00001443338,0.00006516196,0.0004354956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1475026,"threshold_uncertainty_score":0.9999953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166974008741436,"score_gpt":0.2534942260410357,"score_spread":0.2318244859536213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}