{"id":"W2135656427","doi":"10.3109/10717544.2014.993747","title":"Strategies for oral delivery and mitochondrial targeting of CoQ10","year":2014,"lang":"en","type":"article","venue":"Drug Delivery","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Public Health","funders":"","keywords":"Coenzyme Q10; Biopharmaceutical; Bioavailability; Intracellular; Mitochondrion; Pharmacology; Reactive oxygen species; Biology; Computational biology; Chemistry; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005454833,0.0004427375,0.0005859439,0.0004949308,0.0002840545,0.0006987716,0.0005424137,0.000875955,0.002733256],"category_scores_gemma":[0.0002802027,0.0002177219,0.0006061274,0.0002429988,0.0004177968,0.0008524603,0.0008152844,0.001380901,0.001059527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006014283,"about_ca_system_score_gemma":0.0004017332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006245292,"about_ca_topic_score_gemma":0.0008895353,"domain_scores_codex":[0.9997734,0.00004897761,0.00001348342,0.00005363325,0.00006563104,0.00004487564],"domain_scores_gemma":[0.9999061,0.0000238473,0.0000218414,0.000009070183,0.00002335899,0.0000157962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003789879,0.0003139195,0.0001859616,0.002702853,0.00007064516,0.0006003825,0.0002186771,0.0007640545,0.834276,0.01024215,0.002805723,0.1474407],"study_design_scores_gemma":[0.0001775158,0.002824003,0.001049961,0.0004161209,0.0002107337,0.001721368,0.0002536781,0.00317461,0.7067842,0.004521247,0.2788091,0.00005741414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2423048,0.402417,0.3028771,0.006980917,0.002090519,0.001616775,0.0006077068,0.0009217202,0.04018348],"genre_scores_gemma":[0.633137,0.2272243,0.1076789,0.002041355,0.00041053,0.0009341977,0.0005186034,0.0001721097,0.02788294],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002733256,"threshold_uncertainty_score":0.009143651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006100799356918642,"score_gpt":0.2257065128244105,"score_spread":0.2196057134674918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}